Pre_GI Gene

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Host: NC_007606 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_007606:1515403 Shigella dysenteriae Sd197, complete genome

Host Lineage: Shigella dysenteriae; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain is an isolate from an epidemic in China in the 1950s. Causes bacillary dysentery. This genus is named for the Japanese scientist (Shiga) who first discovered these organisms in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. These organisms are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, causing over 160 million cases of infection and 1 million deaths yearly worldwide. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that can cause an active infection after a very low exposure. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. Shigella dysenteriae is the major cause of Shigella-related deaths in developing nations, mostly in young children.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
15154031516098696cryptic nitrate reductase 2 delta subunit assembly functionQuickGO ontologyBLASTP
15160951516775681cryptic nitrate reductase 2 gamma subunitQuickGO ontologyBLASTP
15168551517748894hypothetical proteinBLASTP
15188611519217357iso-IS1 ORF2QuickGO ontologyBLASTP
15191951519872678putative adhesinQuickGO ontologyBLASTP
152020615224852280putative oxidoreductase major subunitQuickGO ontologyBLASTP
15227341522931198hypothetical proteinBLASTP
15230061523785780putative ARAC-type regulatory proteinQuickGO ontologyBLASTP
15241721524657486hypothetical proteinBLASTP
15249051525300396iso-IS1 ORF2QuickGO ontologyBLASTP
15257121526020309hypothetical proteinBLASTP
152637915274011023hypothetical proteinBLASTP
15277061527915210IS1 ORF2QuickGO ontologyBLASTP
15280661528320255hypothetical proteinBLASTP
15285151528910396iso-IS1 ORF2QuickGO ontologyBLASTP
15290171529355339hypothetical proteinBLASTP
152952215312581737hypothetical protein
153131115325761266unknown protein encoded by bacteriophage BP-933WQuickGO ontologyBLASTP
15326961533409714IS600 ORF2QuickGO ontologyBLASTP
15335501533852303IS600 ORF1QuickGO ontologyBLASTP
15343541534623270hypothetical protein
15346421535052411hypothetical proteinBLASTP
153504915381053057putative oxidaseQuickGO ontologyBLASTP