Pre_GI Gene

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Host: NC_007606 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_007606:3784847 Shigella dysenteriae Sd197, complete genome

Host Lineage: Shigella dysenteriae; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain is an isolate from an epidemic in China in the 1950s. Causes bacillary dysentery. This genus is named for the Japanese scientist (Shiga) who first discovered these organisms in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. These organisms are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, causing over 160 million cases of infection and 1 million deaths yearly worldwide. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that can cause an active infection after a very low exposure. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. Shigella dysenteriae is the major cause of Shigella-related deaths in developing nations, mostly in young children.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
378484737858511005putative regulatorQuickGO ontologyBLASTP
378609037871151026threonine dehydrogenaseQuickGO ontologyBLASTP
3787125378832111972-amino-3-ketobutyrate CoA ligaseQuickGO ontologyBLASTP
37885353789467933ADP-L-glycero-D-mannoheptose-6-epimeraseQuickGO ontologyBLASTP
378947737905231047ADP-heptose--lps heptosyltransferase IIQuickGO ontologyBLASTP
37905273791486960heptosyl transferase IQuickGO ontologyBLASTP
379153437927871254lipid A-coresurface polymer ligase WaaLQuickGO ontologyBLASTP
37928223793595774putative beta14-galactosyltransferase WaaXQuickGO ontologyBLASTP
379362737946551029UDP-galactosegalactosyl LPS alpha12-galactosyltransferaseQuickGO ontologyBLASTP
37946813795373693Lipopolysaccharide core biosynthesis protein rfaYQuickGO ontologyBLASTP
37953833796378996Lipopolysaccharide 12-glucosyltransferaseQuickGO ontologyBLASTP
379639537974111017Lipopolysaccharide 13-galactosyltransferaseQuickGO ontologyBLASTP
37974273798233807putative LPS biosynthesis enzymeQuickGO ontologyBLASTP
379821737993411125glucosyltransferase IQuickGO ontologyBLASTP
379933838003961059lipopolysaccharide core biosynthesis proteinQuickGO ontologyBLASTP
3800809380208612783-deoxy-D-manno-octulosonic-acid transferaseQuickGO ontologyBLASTP
38020943802573480putative enzyme of LPS biosynthesisQuickGO ontologyBLASTP
38026123803421810formamidopyrimidine DNA glycosylaseQuickGO ontologyBLASTP
3803519380368616850S ribosomal subunit protein L33QuickGO ontologyBLASTP
3803707380394323750S ribosomal subunit protein L28QuickGO ontologyBLASTP
38041603804834675DNA repair proteinQuickGO ontologyBLASTP
380492838062201293DfpQuickGO ontologyBLASTP
38062013806656456deoxyuridinetriphosphataseQuickGO ontologyBLASTP
38067213807359639putative transcriptional regulatorQuickGO ontologyBLASTP
38076883808197510putative RNA-directed DNA polymerase msDNA specificQuickGO ontologyBLASTP