Pre_GI Gene

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Host: NC_007606 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_007606:1209132 Shigella dysenteriae Sd197, complete genome

Host Lineage: Shigella dysenteriae; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain is an isolate from an epidemic in China in the 1950s. Causes bacillary dysentery. This genus is named for the Japanese scientist (Shiga) who first discovered these organisms in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. These organisms are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, causing over 160 million cases of infection and 1 million deaths yearly worldwide. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that can cause an active infection after a very low exposure. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. Shigella dysenteriae is the major cause of Shigella-related deaths in developing nations, mostly in young children.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
120913212101451014OppDQuickGO ontologyBLASTP
121014212111461005OppFQuickGO ontologyBLASTP
12111991211606408hypothetical proteinBLASTP
121156312130231461cardiolipin synthaseQuickGO ontologyBLASTP
121339312146461254putative potassium channel proteinQuickGO ontologyBLASTP
12149461215338393hypothetical proteinBLASTP
12167271217092366IS2 ORF1QuickGO ontologyBLASTP
12171161217928813IS2 ORF2QuickGO ontologyBLASTP
12181331218684552DNA invertase-like proteinQuickGO ontologyBLASTP
12187651219067303IS911 ORF1QuickGO ontologyBLASTP
12190941219312219IS911 ORF2QuickGO ontologyBLASTP
12194151219936522IS911 ORF2QuickGO ontologyBLASTP
12201911220910720TonBQuickGO ontologyBLASTP
12209501221348399hypothetical proteinBLASTP
12214531221992540hypothetical proteinBLASTP
12220221222765744hypothetical proteinBLASTP
12231221223760639putative outer membrane proteinQuickGO ontologyBLASTP
12238201224329510hypothetical proteinBLASTP
12243571224572216IS600 ORF2QuickGO ontologyBLASTP
12246141224889276IS1 ORF1QuickGO ontologyBLASTP
12249341225311378IS1 ORF2QuickGO ontologyBLASTP
12257951226142348iso-IS1 ORF2QuickGO ontologyBLASTP
12262041226506303IS600 ORF1QuickGO ontologyBLASTP
12266471227360714IS600 ORF2QuickGO ontologyBLASTP
12276731228479807tryptophan synthase alpha proteinQuickGO ontologyBLASTP
122847912296721194tryptophan synthase beta proteinQuickGO ontologyBLASTP