Pre_GI Gene

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Host: NC_007606 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_007606:2353098 Shigella dysenteriae Sd197, complete genome

Host Lineage: Shigella dysenteriae; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain is an isolate from an epidemic in China in the 1950s. Causes bacillary dysentery. This genus is named for the Japanese scientist (Shiga) who first discovered these organisms in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. These organisms are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, causing over 160 million cases of infection and 1 million deaths yearly worldwide. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that can cause an active infection after a very low exposure. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. Shigella dysenteriae is the major cause of Shigella-related deaths in developing nations, mostly in young children.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
235309823545311434sucrose hydrolaseQuickGO ontologyBLASTP
23545392355534996sucrose operon repressorQuickGO ontologyBLASTP
23557772355995219D-serine permeaseQuickGO ontologyBLASTP
235601323573411329D-serine dehydrataseQuickGO ontologyBLASTP
235744923589871539multidrug resistance protein YQuickGO ontologyBLASTP
235898723601501164multidrug resistance protein KQuickGO ontologyBLASTP
23612362361631396iso-IS1 ORF2QuickGO ontologyBLASTP
23631922363587396iso-IS1 ORF2QuickGO ontologyBLASTP
23647112364986276IS1 ORF1QuickGO ontologyBLASTP
236525323664371185putative enzymeQuickGO ontologyBLASTP
23664722367416945putative receptor proteinQuickGO ontologyBLASTP
236748623691801695putative enzymeQuickGO ontologyBLASTP
236923423704841251putative enzymeQuickGO ontologyBLASTP
23709962371628633hypothetical proteinBLASTP
23719242372199276hypothetical proteinBLASTP
23722762372518243hypothetical proteinBLASTP
23728052373791987putative heat shock proteinQuickGO ontologyBLASTP
237428423755221239putative aminotransferaseQuickGO ontologyBLASTP