Pre_GI Gene

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Host: NC_007606 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_007606:3842708 Shigella dysenteriae Sd197, complete genome

Host Lineage: Shigella dysenteriae; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain is an isolate from an epidemic in China in the 1950s. Causes bacillary dysentery. This genus is named for the Japanese scientist (Shiga) who first discovered these organisms in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. These organisms are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, causing over 160 million cases of infection and 1 million deaths yearly worldwide. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that can cause an active infection after a very low exposure. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. Shigella dysenteriae is the major cause of Shigella-related deaths in developing nations, mostly in young children.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
38445133844788276IS1 ORF1QuickGO ontologyBLASTP
38448333845210378IS1 ORF2QuickGO ontologyBLASTP
38457983846175378IS1 ORF2QuickGO ontologyBLASTP
38462203846495276IS1 ORF1QuickGO ontologyBLASTP
38468923847227336hypothetical proteinBLASTP
38479633848751789ATP-binding component of phosphonate transportQuickGO ontologyBLASTP
384877638497921017periplasmic binding protein component of Pn transporterQuickGO ontologyBLASTP
38498473850677831membrane channel protein component of Pn transporterQuickGO ontologyBLASTP
38506983851423726putative transcriptional regulatorQuickGO ontologyBLASTP
38518603852444585phosphonate metabolismQuickGO ontologyBLASTP
385244438535081065phosphonate metabolismQuickGO ontologyBLASTP
38535013854346846phosphonate metabolismQuickGO ontologyBLASTP
38543433855101759ATP-binding component of phosphonate transportQuickGO ontologyBLASTP
38552123855892681ATP-binding component of phosphonate transportQuickGO ontologyBLASTP
385588938569411053phosphonate metabolismQuickGO ontologyBLASTP
38569413857498558ATP-binding component of phosphonate transportQuickGO ontologyBLASTP
38574853857919435putative regulator phn operonQuickGO ontologyBLASTP
38579213858679759phosphonate metabolismQuickGO ontologyBLASTP
38587563859085330Z5694-like proteinQuickGO ontologyBLASTP
38591543859909756hypothetical proteinBLASTP
385989938621632265putative histidine kinaseQuickGO ontologyBLASTP
386227738637641488putative ATP-binding protein of ribose ABC transport systemQuickGO ontologyBLASTP