Pre_GI Gene

Some Help

Host: NC_007606 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_007606:4182188 Shigella dysenteriae Sd197, complete genome

Host Lineage: Shigella dysenteriae; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain is an isolate from an epidemic in China in the 1950s. Causes bacillary dysentery. This genus is named for the Japanese scientist (Shiga) who first discovered these organisms in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. These organisms are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, causing over 160 million cases of infection and 1 million deaths yearly worldwide. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that can cause an active infection after a very low exposure. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. Shigella dysenteriae is the major cause of Shigella-related deaths in developing nations, mostly in young children.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
418218841836451458putative peptide transporterQuickGO ontologyBLASTP
41840984184811714IS600 ORF2QuickGO ontologyBLASTP
41852704186106837IS911 ORF2QuickGO ontologyBLASTP
4186256418632671tRNA-LeuQuickGO ontology
41872334187550318TransposaseQuickGO ontologyBLASTP
41883234188718396iso-IS1 ORF2QuickGO ontologyBLASTP
41887424189452711putative transposaseQuickGO ontologyBLASTP
41900764190324249hypothetical proteinBLASTP
41905194190914396iso-IS1 ORF2QuickGO ontologyBLASTP
41915664192180615putative positive transcription regulatorQuickGO ontologyBLASTP
419218541957783594putative sensor for regulator EvgAQuickGO ontologyBLASTP
419593841974761539ISSfl4 ORF3QuickGO ontologyBLASTP
41975264197873348ISSfl4 ORF2QuickGO ontologyBLASTP
41989204199255336ISSfl4 ORF2QuickGO ontologyBLASTP
41992754199685411hypothetical proteinBLASTP
41998174200092276IS1 ORF1QuickGO ontologyBLASTP
42001374200514378IS1 ORF2QuickGO ontologyBLASTP
42007094201422714IS600 ORF2QuickGO ontologyBLASTP
42014194201622204hypothetical proteinBLASTP