Pre_GI Gene

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Host: NC_008150 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_008150:1384102 Yersinia pestis Antiqua, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Isolated from a soil sample from the Republic of Congo. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
13841021384950849hypothetical proteinBLASTP
138498013861101131hypothetical proteinBLASTP
138612113871701050hypothetical proteinBLASTP
13871871387426240hypothetical proteinBLASTP
13875121388111600trp repressor binding proteinQuickGO ontologyBLASTP
138850513896831179hypothetical proteinBLASTP
138980913912241416D-serineD-alanineglycine transporterQuickGO ontologyBLASTP
1391586139166176tRNA-LysQuickGO ontologyBLASTP
13923481392899552attachment invasion locus proteinQuickGO ontologyBLASTP
13932391393493255hypothetical proteinBLASTP
13935211393865345hypothetical proteinBLASTP
13939901394214225hypothetical proteinBLASTP
13948771395533657response regulator proteinQuickGO ontologyBLASTP
139550513973581854excinuclease ABC subunit CQuickGO ontologyBLASTP
13974171397965549CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferaseQuickGO ontologyBLASTP
1398110139818576tRNA-GlyQuickGO ontology
1398238139831174tRNA-CysQuickGO ontologyBLASTP
1398322139840786tRNA-LeuQuickGO ontologyBLASTP
13987051399262558hypothetical proteinBLASTP
13993311399558228replicative DNA helicaseQuickGO ontologyBLASTP
14008951401056162hypothetical proteinBLASTP
14010821401426345hypothetical proteinBLASTP
14016461402605960putative transposaseQuickGO ontologyBLASTP