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Query: NC_008150:1384102:1393239 Yersinia pestis Antiqua, complete genome

Start: 1393239, End: 1393493, Length: 255

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Isolated from a soil sample from the Republic of Congo. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017168:3535786:355059935505993550853255Yersinia pestis A1122 chromosome, complete genomehypothetical protein1e-25115
NC_010465:2582080:259198825919882592242255Yersinia pseudotuberculosis YPIII, complete genomehypothetical protein1e-25115
NC_005810:1663672:167888716788871679141255Yersinia pestis biovar Microtus str. 91001, complete genomehypothetical protein1e-25115
NC_003143:2101902:211016021101602110414255Yersinia pestis CO92, complete genomehypothetical protein1e-25115
NC_004088:2691565:270641427064142706668255Yersinia pestis KIM, complete genomehypothetical protein1e-25115
NC_006155:2084669:209178620917862092040255Yersinia pseudotuberculosis IP 32953, complete genomehypothetical protein1e-25115
NC_010159:2128157:213720421372042137458255Yersinia pestis Angola, complete genomehypothetical protein1e-25115
NC_009381:1414985:142577114257711426025255Yersinia pestis Pestoides F chromosome, complete genomehypothetical protein1e-25115
NC_009708:2537557:256202425620242562278255Yersinia pseudotuberculosis IP 31758 chromosome, complete genomehypothetical protein1e-25115
NC_008800:2013450:201837520183752018629255Yersinia enterocolitica subsp. enterocolitica 8081 chromosome,hypothetical protein7e-1889.4
NC_015224:2061951:207337320733732073627255Yersinia enterocolitica subsp. palearctica 105.5R(r) chromosome,hypothetical protein3e-1787