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Query: NC_015848:3343731:3361900 Mycobacterium canettii CIPT 140010059, complete genome

Start: 3361900, End: 3363156, Length: 1257

Host Lineage: Mycobacterium canettii; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: The Republic of Djibouti, Africa appears to be an exceptional place in terms of tuberculosis (TB) caused by Mycobacterium canettii, a highly unusual tubercle bacillus with unusual smooth colony morphology (STB) related to the M. tuberculosis complex (MTBC). M. canettii was first isolated from a 20-year-old French farmer suffering from pulmonary tuberculosis by G. Canetti in 1969. Since then, this strain has been isolated on rare occasions from patients who lived or were presumably infected in East Africa. It tends to preferentially affect children and foreigners in the Horn of Africa. M. canettii, a possible ancestor of the MTBC, is found almost exclusively in the Horn of Africa where TB is thought to have emerged about 40 000 years ago, coinciding with the expansion of human population out of Africa. The geographical restriction of M. canettii isolates and contrasting genetic diversity are characteristics compatible with a non-human reservoir. With the larger pan-genome reflecting the ancestral, wider gene pool of tubercle bacilli, their lower virulence and faster growth, especially at temperatures below 37 degrees C, plausibly reflecting broader environmental adaptability, STB strains might thus come nearer to the as-yet-unknown missing link between the obligate pathogen M. tuberculosis and environmental mycobacteria (adapted from PMIDs 20831613 and 23291586). Mycobacteria have an unusual outer membrane approximately 8nm thick, despite being considered Gram-positive. The outer membrane and the mycolic acid-arabinoglactan-peptidoglycan polymer form the cell wall, which constitutes an efficient permeability barrier in conjunction with the cell inner membrane.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_019950:3306419:3326209332620933274651257Mycobacterium canettii CIPT 140060008 complete genomePutative trans-acting enoyl reductase0718
NC_000962:3288464:3305279330527933065351257Mycobacterium tuberculosis H37Rv, complete genomehypothetical protein0716
NC_002945:3246278:3261967326196732632231257Mycobacterium bovis AF2122/97, complete genomehypothetical protein0716
NC_008769:3242453:3259440325944032606961257Mycobacterium bovis BCG str. Pasteur 1173P2, complete genomehypothetical protein0716
NC_009525:3300456:3317271331727133185271257Mycobacterium tuberculosis H37Ra, complete genomehypothetical protein0716
NC_012207:3237440:3252267325226732535231257Mycobacterium bovis BCG str. Tokyo 172, complete genomehypothetical protein0716
NC_002755:3282785:3299600329960033008561257Mycobacterium tuberculosis CDC1551, complete genomehypothetical protein0716
NC_009565:3299937:3316752331675233180081257Mycobacterium tuberculosis F11, complete genomehypothetical protein0716
NC_016804:3221818:3238805323880532400611257Mycobacterium bovis BCG str. Mexico chromosome, complete genomeTrans-acting enoyl reductase0716
NC_017026:3282405:3299224329922433004801257Mycobacterium tuberculosis RGTB327 chromosome, complete genomeTrans-acting enoyl reductase0716
NC_002677:173170:1731701731701744261257Mycobacterium leprae TN, complete genomehypothetical protein4e-177620
NC_011896:173197:1731971731971744531257Mycobacterium leprae Br4923, complete genomehypothetical protein4e-177620
NC_010612:4654936:4655640465564046568961257Mycobacterium marinum M, complete genomehypothetical protein8e-128457
NC_008541:4066294:4067228406722840684601233Arthrobacter sp. FB24 chromosome 1, complete sequenceSaccharopine dehydrogenase5e-67255
NC_008740:1635137:1653147165314716543881242Marinobacter aquaeolei VT8, complete genomeSaccharopine dehydrogenase9e-50197
NC_017506:1832443:1850088185008818513291242Marinobacter adhaerens HP15 chromosome, complete genomesaccharopine dehydrogenase-like protein4e-48192
NC_014960:1670778:1673710167371016747651056Anaerolinea thermophila UNI-1, complete genomesaccharopine dehydrogenase family protein2e-1170.9
NC_015957:7408466:7433212743321274342401029Streptomyces violaceusniger Tu 4113 chromosome, complete genomeSaccharopine dehydrogenase6e-1065.9
NC_020126:204216:2217962217962229141119Myxococcus stipitatus DSM 14675, complete genomehypothetical protein9e-1065.1
NC_009142:1701000:1717623171762317186721050Saccharopolyspora erythraea NRRL 2338, complete genomesaccharopine dehydrogenase1e-0861.2
NC_007908:4677856:4677856467785646789711116Rhodoferax ferrireducens T118, complete genomeSaccharopine dehydrogenase1e-0861.2
NC_004129:3965947:3967677396767739687561080Pseudomonas fluorescens Pf-5, complete genomehypothetical protein2e-0757.4
NC_012660:4669500:468146846814684682445978Pseudomonas fluorescens SBW25 chromosome, complete genomehypothetical protein3e-0756.6