Pre_GI Gene

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Host: NC_017026 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017026:3282405 Mycobacterium tuberculosis RGTB327 chromosome, complete genome

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
328240532836461242transposase for insertion sequence element IS1533QuickGO ontologyBLASTP
32836463284176531transposaseQuickGO ontologyBLASTP
32840643284447384transposase for insertion sequence element IS1533QuickGO ontologyBLASTP
32845653285266702putative lipoprotein LPPXQuickGO ontologyBLASTP
328544432866461203polyketide synthase pks1QuickGO ontologyBLASTP
328642932903073879polyketide synthaseQuickGO ontologyBLASTP
329029232917851494putative polyketide synthaseQuickGO ontologyBLASTP
329178232938992118acyl-CoA synthetaseQuickGO ontologyBLASTP
32939163294515600hypothetical proteinBLASTP
329454132964001860acyl-CoA synthetaseQuickGO ontologyBLASTP
329704832981931146oxidoreductaseQuickGO ontologyBLASTP
32983863299198813methyltransferaseQuickGO ontologyBLASTP
329922433004801257Trans-acting enoyl reductaseQuickGO ontologyBLASTP
33006113301336726hypothetical proteinBLASTP
33015253302490966hypothetical proteinBLASTP
33026133303344732hypothetical proteinBLASTP