Pre_GI Gene

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Host: NC_011896 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_011896:173197 Mycobacterium leprae Br4923, complete genome

Host Lineage: Mycobacterium leprae; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain was isolated from a human skin biopsy in Brazil, and passaged in nude mice and armadillos. The bacterium is a close relative of M. tuberculosis. However, compared to the latter, the genome of M. leprae is smaller due to reductive genome evolution, with many important metabolic activities including siderophore production, part of the oxidative chain, most of the microaerophilic and anaerobic respiratory chains, and numerous catabolic systems and their regulatory circuits eliminated due to extensive recombination events between dispersed repetitive sequences. It is evident that this species has undergone massive genome reduction over time as a result of its parasitic nature, discarding more than half its genes and rendering it the most striking example of genome reduction in a microbial pathogen.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
1731971744531257hypothetical proteinBLASTP
174493175305813hypothetical proteinBLASTP
1754681766161149putative oxidoreductaseQuickGO ontologyBLASTP
1771971792392043putative acyl-CoA synthetaseQuickGO ontologyBLASTP
179283179915633hypothetical proteinBLASTP
1800541821772124putative acyl-CoA synthetaseQuickGO ontologyBLASTP
1822001885116312putative polyketide synthaseQuickGO ontologyBLASTP
188578189279702putative lipoproteinQuickGO ontologyBLASTP
1892801919882709hypothetical proteinBLASTP