Pre_GI Gene

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Host: NC_009525 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_009525:3300456 Mycobacterium tuberculosis H37Ra, complete genome

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain (H37Ra; ATCC 25177) is an avirulent strain derived from its virulent parent strain H37 (isolated from a 19 year-old male patient with chronic pulmonary tuberculosis by Edward R. Baldwin in 1905). Causative agent of tuberculosis. This genus comprises a number of Gram-positive, acid-fast, rod-shaped aerobic bacteria and is the only member of the family Mycobacteriaceae within the order Actinomycetales. Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
330045633016971242ISMt3 transposase AQuickGO ontologyBLASTP
33016973302227531ISMt3 transposase B1QuickGO ontologyBLASTP
33017823302498717ISMt3 transposase B2QuickGO ontologyBLASTP
33026163303317702putative conserved lipoprotein LppXQuickGO ontologyBLASTP
330349533083454851putative polyketide synthase Pks1QuickGO ontologyBLASTP
330834233098321491polyketide synthase Pks15QuickGO ontologyBLASTP
330982933119462118fatty-acid-CoA ligase FadD22QuickGO ontologyBLASTP
33119633312562600hypothetical proteinBLASTP
331258833144471860fatty-acid-CoA ligase FadD29QuickGO ontologyBLASTP
331509533162401146N5N10-methylenetetrahydromethanopterin reductase-related proteinQuickGO ontologyBLASTP
33164333317245813putative methyltransferaseQuickGO ontologyBLASTP
331727133185271257hypothetical proteinBLASTP
33186583319383726hypothetical proteinBLASTP
33195723320537966hypothetical proteinBLASTP
33206603321391732hypothetical proteinBLASTP
33214623322289828glycosyl transferaseQuickGO ontologyBLASTP