Pre_GI: BLASTP Hits

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Query: NC_015848:3175692:3183612 Mycobacterium canettii CIPT 140010059, complete genome

Start: 3183612, End: 3183953, Length: 342

Host Lineage: Mycobacterium canettii; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: The Republic of Djibouti, Africa appears to be an exceptional place in terms of tuberculosis (TB) caused by Mycobacterium canettii, a highly unusual tubercle bacillus with unusual smooth colony morphology (STB) related to the M. tuberculosis complex (MTBC). M. canettii was first isolated from a 20-year-old French farmer suffering from pulmonary tuberculosis by G. Canetti in 1969. Since then, this strain has been isolated on rare occasions from patients who lived or were presumably infected in East Africa. It tends to preferentially affect children and foreigners in the Horn of Africa. M. canettii, a possible ancestor of the MTBC, is found almost exclusively in the Horn of Africa where TB is thought to have emerged about 40 000 years ago, coinciding with the expansion of human population out of Africa. The geographical restriction of M. canettii isolates and contrasting genetic diversity are characteristics compatible with a non-human reservoir. With the larger pan-genome reflecting the ancestral, wider gene pool of tubercle bacilli, their lower virulence and faster growth, especially at temperatures below 37 degrees C, plausibly reflecting broader environmental adaptability, STB strains might thus come nearer to the as-yet-unknown missing link between the obligate pathogen M. tuberculosis and environmental mycobacteria (adapted from PMIDs 20831613 and 23291586). Mycobacteria have an unusual outer membrane approximately 8nm thick, despite being considered Gram-positive. The outer membrane and the mycolic acid-arabinoglactan-peptidoglycan polymer form the cell wall, which constitutes an efficient permeability barrier in conjunction with the cell inner membrane.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_019950:3139865:314799531479953148336342Mycobacterium canettii CIPT 140060008 complete genomePutative CRISPR-associated RNAse Cas21e-59228
NC_002945:3073370:308018730801873080528342Mycobacterium bovis AF2122/97, complete genomehypothetical protein4e-59226
NC_002755:3110929:311783031178303118171342Mycobacterium tuberculosis CDC1551, complete genomeCRISPR-associated protein Cas24e-59226
NC_008769:3070266:307760230776023077943342Mycobacterium bovis BCG str. Pasteur 1173P2, complete genomehypothetical protein4e-59226
NC_012207:3063039:307037530703753070716342Mycobacterium bovis BCG str. Tokyo 172, complete genomehypothetical protein4e-59226
NC_009525:3128786:313561631356163135957342Mycobacterium tuberculosis H37Ra, complete genomehypothetical protein4e-59226
NC_000962:3116818:312362531236253123966342Mycobacterium tuberculosis H37Rv, complete genomehypothetical protein4e-59226
NC_009565:3128094:313525431352543135595342Mycobacterium tuberculosis F11, complete genomehypothetical protein4e-59226
NC_012943:1279228:128987012898701290211342Mycobacterium tuberculosis KZN 1435 chromosome, complete genomehypothetical protein4e-59226
NC_016768:1279178:128981412898141290155342Mycobacterium tuberculosis KZN 4207 chromosome, complete genomehypothetical protein4e-59226
NC_016804:3049631:305696730569673057308342Mycobacterium bovis BCG str. Mexico chromosome, complete genomehypothetical protein4e-59226
NC_017026:3110155:311746831174683117809342Mycobacterium tuberculosis RGTB327 chromosome, complete genomehypothetical protein4e-59226
NC_015873:1487127:149458314945831494888306Megasphaera elsdenii DSM 20460, complete genomeCRISPR-associated protein cas22e-1064.3
NC_008639:2358592:239252523925252392794270Chlorobium phaeobacteroides DSM 266, complete genomeCRISPR-associated protein Cas22e-0651.2
NC_008554:1664131:168328116832811683559279Syntrophobacter fumaroxidans MPOB, complete genomeCRISPR-associated protein Cas25e-0650.1