Pre_GI Gene

Some Help

Host: NC_009525 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_009525:3128786 Mycobacterium tuberculosis H37Ra, complete genome

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain (H37Ra; ATCC 25177) is an avirulent strain derived from its virulent parent strain H37 (isolated from a 19 year-old male patient with chronic pulmonary tuberculosis by Edward R. Baldwin in 1905). Causative agent of tuberculosis. This genus comprises a number of Gram-positive, acid-fast, rod-shaped aerobic bacteria and is the only member of the family Mycobacteriaceae within the order Actinomycetales. Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
312878631301951410putative transposaseQuickGO ontologyBLASTP
31301923131004813hypothetical proteinBLASTP
31325343133418885IS6110 transposaseQuickGO ontologyBLASTP
31334693133795327IS6110 hypothetical proteinQuickGO ontologyBLASTP
31356163135957342hypothetical proteinBLASTP
313595831369741017hypothetical proteinBLASTP
313698731381351149hypothetical proteinBLASTP
313823131393581128hypothetical proteinBLASTP
31393553140263909hypothetical proteinBLASTP
31402443140954711hypothetical proteinBLASTP
31409643141338375hypothetical proteinBLASTP
314133531437642430hypothetical proteinBLASTP
31437613144705945hypothetical proteinBLASTP
31448833145530648hypothetical proteinBLASTP
31457013146585885hypothetical proteinBLASTP
31465883147475888hypothetical proteinBLASTP
31477803148325546hypothetical proteinBLASTP
31483223149047726hypothetical proteinBLASTP