Pre_GI: BLASTP Hits

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Query: NC_009525:3128786:3144883 Mycobacterium tuberculosis H37Ra, complete genome

Start: 3144883, End: 3145530, Length: 648

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain (H37Ra; ATCC 25177) is an avirulent strain derived from its virulent parent strain H37 (isolated from a 19 year-old male patient with chronic pulmonary tuberculosis by Edward R. Baldwin in 1905). Causative agent of tuberculosis. This genus comprises a number of Gram-positive, acid-fast, rod-shaped aerobic bacteria and is the only member of the family Mycobacteriaceae within the order Actinomycetales. Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_000962:3116818:313289231328923133539648Mycobacterium tuberculosis H37Rv, complete genomehypothetical protein3e-102370
NC_016768:1279178:128015712801571280879723Mycobacterium tuberculosis KZN 4207 chromosome, complete genomehypothetical protein6e-102369
NC_012943:1279228:128019512801951280935741Mycobacterium tuberculosis KZN 1435 chromosome, complete genomehypothetical protein6e-102369
NC_009565:3128094:314453031445303145270741Mycobacterium tuberculosis F11, complete genomehypothetical protein6e-102369
NC_002755:3110929:312710631271063127846741Mycobacterium tuberculosis CDC1551, complete genomehypothetical protein6e-102369
NC_012207:3063039:307965130796513080298648Mycobacterium bovis BCG str. Tokyo 172, complete genomehypothetical protein2e-99361
NC_002945:3073370:308946330894633090110648Mycobacterium bovis AF2122/97, complete genomehypothetical protein2e-99361
NC_008769:3070266:308687830868783087525648Mycobacterium bovis BCG str. Pasteur 1173P2, complete genomehypothetical protein2e-99361
NC_016804:3049631:306624330662433066890648Mycobacterium bovis BCG str. Mexico chromosome, complete genomehypothetical protein2e-99361
NC_017026:3110155:312673531267353127280546Mycobacterium tuberculosis RGTB327 chromosome, complete genomehypothetical protein2e-81301
NC_009525:3128786:314778031477803148325546Mycobacterium tuberculosis H37Ra, complete genomehypothetical protein2e-80298
NC_000962:3116818:313578831357883136333546Mycobacterium tuberculosis H37Rv, complete genomehypothetical protein2e-80298
NC_012207:3063039:308254730825473083092546Mycobacterium bovis BCG str. Tokyo 172, complete genomehypothetical protein2e-80298
NC_009565:3128094:314742631474263147971546Mycobacterium tuberculosis F11, complete genomehypothetical protein2e-80298
NC_016804:3049631:306913930691393069684546Mycobacterium bovis BCG str. Mexico chromosome, complete genomehypothetical protein2e-80298
NC_002945:3073370:309235930923593092904546Mycobacterium bovis AF2122/97, complete genomehypothetical protein1e-79295
NC_019950:3139865:315887031588703159415546Mycobacterium canettii CIPT 140060008 complete genomehypothetical protein3e-69261
NC_015848:3175692:319448731944873195032546Mycobacterium canettii CIPT 140010059, complete genomehypothetical protein3e-69261
NC_015690:1109335:111008211100821110666585Paenibacillus mucilaginosus KNP414 chromosome, complete genomehypothetical protein4e-1684.7
NC_016935:1636278:163813316381331638717585Paenibacillus mucilaginosus 3016 chromosome, complete genomehypothetical protein1e-1582.8