Pre_GI: BLASTP Hits

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Query: NC_009525:3128786:3141335 Mycobacterium tuberculosis H37Ra, complete genome

Start: 3141335, End: 3143764, Length: 2430

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain (H37Ra; ATCC 25177) is an avirulent strain derived from its virulent parent strain H37 (isolated from a 19 year-old male patient with chronic pulmonary tuberculosis by Edward R. Baldwin in 1905). Causative agent of tuberculosis. This genus comprises a number of Gram-positive, acid-fast, rod-shaped aerobic bacteria and is the only member of the family Mycobacteriaceae within the order Actinomycetales. Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_000962:3116818:3129344312934431317732430Mycobacterium tuberculosis H37Rv, complete genomehypothetical protein01673
NC_017026:3110155:3123187312318731256162430Mycobacterium tuberculosis RGTB327 chromosome, complete genomehypothetical protein01669
NC_002755:3110929:3123549312354931260022454Mycobacterium tuberculosis CDC1551, complete genomeCRISPR-associated TM1811 family protein01668
NC_009565:3128094:3140973314097331434112439Mycobacterium tuberculosis F11, complete genomehypothetical protein01667
NC_002945:3073370:3085906308590630883442439Mycobacterium bovis AF2122/97, complete genomehypothetical protein01667
NC_012207:3063039:3076094307609430785322439Mycobacterium bovis BCG str. Tokyo 172, complete genomehypothetical protein01667
NC_008769:3070266:3083321308332130857592439Mycobacterium bovis BCG str. Pasteur 1173P2, complete genomehypothetical protein01667
NC_012943:1279228:1282054128205412844922439Mycobacterium tuberculosis KZN 1435 chromosome, complete genomehypothetical protein01667
NC_016768:1279178:1281998128199812844362439Mycobacterium tuberculosis KZN 4207 chromosome, complete genomehypothetical protein01667
NC_016804:3049631:3062686306268630651242439Mycobacterium bovis BCG str. Mexico chromosome, complete genomehypothetical protein01667
NC_015848:3175692:3189336318933631917772442Mycobacterium canettii CIPT 140010059, complete genomehypothetical protein01481
NC_019950:3139865:3153719315371931561602442Mycobacterium canettii CIPT 140060008 complete genomeConserved CRISPR-associated protein of unknown function Cas1001481
NC_015873:1487127:1494971149497114974662496Megasphaera elsdenii DSM 20460, complete genomeCRISPR-associated protein3e-121436
NC_011529:806000:8208468208468231792334Thermococcus onnurineus NA1, complete genomehypothetical protein3e-60233
NC_009486:1103915:1124643112464311268502208Thermotoga petrophila RKU-1 chromosome, complete genomemetal dependent phosphohydrolase2e-58228
NC_013407:1205747:1207012120701212093182307Methanocaldococcus vulcanius M7, complete genomeCRISPR-associated protein, Csm1 family3e-55217
NC_013501:1881692:1897037189703718994392403Rhodothermus marinus DSM 4252, complete genomeCRISPR-associated protein, Csm1 family1e-53211
NC_015562:1230532:1250698125069812533222625Methanotorris igneus Kol 5 chromosome, complete genomeCRISPR-associated protein, Csm1 family1e-51205
NC_014212:670996:6883946883946908202427Meiothermus silvanus DSM 9946 chromosome, complete genomeCRISPR-associated protein, Csm1 family6e-49196
NC_000961:135493:1403131403131423852073Pyrococcus horikoshii OT3, complete genomehypothetical protein4e-48193
NC_015565:624298:6242986242986267392442Desulfotomaculum carboxydivorans CO-1-SRB chromosome, completeCRISPR-associated protein, Csm1 family5e-44180
NC_000916:983500:9968149968149992822469Methanothermobacter thermautotrophicus str. Delta H, completehypothetical protein6e-44179
NC_011060:2525367:2537649253764925399342286Pelodictyon phaeoclathratiforme BU-1, complete genomeCRISPR-associated protein, Csm1 family6e-35149
NC_011978:699500:7011077011077025311425Thermotoga neapolitana DSM 4359, complete genomeCRISPR-associated protein, Csm1 family8e-35149
NC_009718:1470972:1497646149764615001382493Fervidobacterium nodosum Rt17-B1, complete genomemetal dependent phosphohydrolase7e-34146
NC_013926:974668:9877569877569900232268Aciduliprofundum boonei T469 chromosome, complete genomeCRISPR-associated protein, Csm1 family1e-31139
NC_014377:532816:5333905333905357562367Thermosediminibacter oceani DSM 16646 chromosome, complete genomeCRISPR-associated protein, Csm1 family9e-30132
NC_014836:1108919:1114981111498111177492769Desulfurispirillum indicum S5 chromosome, complete genomeCsm1 family CRISPR-associated protein1e-28129
NC_002689:78297:1158281158281181552328Thermoplasma volcanium GSS1, complete genomePredicted hydrolase (HD superfamily)3e-28127
NC_015388:1913118:1918900191890019215092610Desulfobacca acetoxidans DSM 11109 chromosome, complete genomeCRISPR-associated protein, Csm1 family9e-25115
NC_006300:1624254:1642744164274416448852142Mannheimia succiniciproducens MBEL55E, complete genomehypothetical protein8e-23109
NC_008554:1664131:1672747167274716752932547Syntrophobacter fumaroxidans MPOB, complete genomeCRISPR-associated protein, Csm1 family4e-20100
NC_008639:2358592:2371523237152323738112289Chlorobium phaeobacteroides DSM 266, complete genomeCRISPR-associated protein, Csm1 family7e-2099.8
NC_016940:190986:2042202042202069312712Saprospira grandis str. Lewin chromosome, complete genomeCsm1 family CRISPR-associated protein7e-1686.7
NC_014926:819163:8297318297318321692439Thermovibrio ammonificans HB-1 chromosome, complete genomeCRISPR-associated protein, Csm1 family3e-1480.9
NC_016610:2489415:2500481250048125019231443Tannerella forsythia ATCC 43037 chromosome, complete genomehypothetical protein1e-0862.4