Pre_GI Gene

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Host: NC_012943 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_012943:1279228 Mycobacterium tuberculosis KZN 1435 chromosome, complete genome

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: M. tuberculosis strain KZN 1435 was isolated from a patient in KwaZulu-Natal, South Africa. This strain is multidrug-resistant (resistant to isoniazid and rifampin). This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. This species is responsible for more morbidity in humans than any other bacterial disease. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. The envelope contains the typical polypeptide layer, the peptidoglycan layer, and free lipids. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. These fatty acid-carbohydrate complexes inhibit phago-lysosome fusion and are often considered to be indicators of virulent strains. The cell envelope also includes adhesins and aggressions, but does not contain any known toxins. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
12783291279231903hypothetical proteinBLASTP
12792281280118891hypothetical proteinBLASTP
12801951280935741hypothetical proteinBLASTP
12811131282057945hypothetical proteinBLASTP
128205412844922439hypothetical proteinBLASTP
12844891284863375hypothetical proteinBLASTP
12848731285583711csm3 family CRISPR-associated ramp proteinQuickGO ontologyBLASTP
12855641286472909csm4 family CRISPR-associated ramp proteinQuickGO ontologyBLASTP
128646912875961128csm5 family CRISPR-associated ramp proteinQuickGO ontologyBLASTP
128759312888401248hypothetical proteinBLASTP
128884412898691026hypothetical proteinBLASTP
12898701290211342hypothetical proteinBLASTP
12919041292230327transposaseQuickGO ontologyBLASTP
12922811293165885transposaseQuickGO ontologyBLASTP
12946211295433813hypothetical proteinBLASTP
129543012968391410transposaseQuickGO ontologyBLASTP
12969101297518609hypothetical proteinBLASTP
12975181297916399transposaseQuickGO ontologyBLASTP
12979381298249312hypothetical proteinBLASTP
12983541298623270hypothetical proteinBLASTP
129884512999961152hypothetical proteinBLASTP