Pre_GI Gene

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Host: NC_017026 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017026:3110155 Mycobacterium tuberculosis RGTB327 chromosome, complete genome

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
31101553110583429hypothetical proteinBLASTP
311065431120631410transposaseQuickGO ontologyBLASTP
31120603113022963hypothetical proteinBLASTP
31144063115290885transposase IS6110QuickGO ontologyBLASTP
31153413115667327putative transposaseQuickGO ontologyBLASTP
31157033115915213hypothetical protein
31174683117809342hypothetical proteinBLASTP
311781031188261017CRISPR-associated protein Cas1QuickGO ontologyBLASTP
311883931200861248hypothetical proteinBLASTP
312008331212101128hypothetical proteinBLASTP
31212073122115909csm4 family CRISPR-associated ramp proteinQuickGO ontologyBLASTP
31220963122806711hypothetical proteinBLASTP
31228163123190375hypothetical proteinBLASTP
312318731256162430hypothetical proteinBLASTP
31256133126557945CRISPR-associated protein Cas6QuickGO ontologyBLASTP
31267353127280546hypothetical proteinBLASTP
31275523128436885hypothetical proteinBLASTP