Pre_GI Gene

Some Help

Host: NC_016768 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_016768:1279178 Mycobacterium tuberculosis KZN 4207 chromosome, complete genome

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
12791781280062885hypothetical proteinBLASTP
12801571280879723hypothetical proteinBLASTP
12810571282001945hypothetical proteinBLASTP
128199812844362439hypothetical proteinBLASTP
12844331284807375hypothetical proteinBLASTP
12848171285527711hypothetical proteinBLASTP
12855081286416909hypothetical proteinBLASTP
128641312875401128hypothetical proteinBLASTP
128753712887841248hypothetical proteinBLASTP
128879712898131017hypothetical proteinBLASTP
12898141290155342hypothetical proteinBLASTP
12918481292174327transposaseQuickGO ontologyBLASTP
12922251293109885transposaseQuickGO ontologyBLASTP
12945651295377813hypothetical proteinBLASTP
129537412967831410transposaseQuickGO ontologyBLASTP
12968541297462609hypothetical proteinBLASTP
12974621297860399transposaseQuickGO ontologyBLASTP
12978821298193312hypothetical proteinBLASTP
12982981298555258hypothetical proteinBLASTP
129878912999401152hypothetical proteinBLASTP