Pre_GI Gene

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Host: NC_000962 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_000962:3116818 Mycobacterium tuberculosis H37Rv, complete genome

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain has been derived from the original human-lung H37 isolate in 1934, and has been used extensively worldwide in biomedical research. Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
311681831182271410PROBABLE TRANSPOSASEQuickGO ontologyBLASTP
31182243119036813hypothetical proteinBLASTP
31205663121504939PROBABLE TRANSPOSASEQuickGO ontologyBLASTP
31215013121827327PROBABLE TRANSPOSASEQuickGO ontologyBLASTP
31236253123966342hypothetical proteinBLASTP
312396731249831017hypothetical proteinBLASTP
312499631261441149hypothetical proteinBLASTP
312624031273671128hypothetical proteinBLASTP
31273643128272909hypothetical proteinBLASTP
31282533128963711hypothetical proteinBLASTP
31289733129347375hypothetical proteinBLASTP
312934431317732430hypothetical proteinBLASTP
31317703132714945hypothetical proteinBLASTP
31328923133539648hypothetical proteinBLASTP
31337093134593885hypothetical proteinBLASTP
31345963135483888hypothetical proteinBLASTP
31357883136333546hypothetical proteinBLASTP