Pre_GI Island

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n1_4mer:GRV/n1_4mer:RV = (Global Relative Variance of OU patterns) / (Local Relative Variance of OU patterns)

n0_4mer:D = Distance between local and global OU patterns

n0_4mer:PS = Distance between 2 strands of same DNA molecule

Selected loci indicated by large D, increased GRV associated with decreased RV and moderate increase in PS

NC_017516: Neisseria meningitidis H44/76 chromosome, complete genome

NCBI: NC_017516

Host Lineage: Neisseria meningitidis; Neisseria; Neisseriaceae; Neisseriales; Proteobacteria; Bacteria

General Information: The second of two pathogenic Neisseria, this organism causes septicemia and is the leading cause of life-threatening meningitis (inflammation of the meninges, the membrane surrounding the brain and spinal cord) in children. This organism typically residies in the nasopharynx cavity but can invade the respiratory epthelial barrier, cross into the bloodstream and the blood brain barrier, and cause inflammation of the meninges. Pathogenicity factors include the surface proteins (porins and opacity proteins), and the type IV pilus (which is also found in Neisseria gonorrhoeae). This organism, like Neisseria gonorrhoeae, is naturally competent, and protein complexes at the cell surface recognize the uptake signal sequence in extracellular DNA, an 8mer that is found at high frequency in Neisseria chromosomal DNA.

Islands with an asterisk (*) contain ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

#StartEndLengthIsland TextGRV_RVDPSNeighboursClusterSub ClusterBLASTNKey Word ConfirmationOther DB ConfirmationDownload Island
196879*12489528017Island text1.771334.157754.8899Neighbours24BLASTN+96879.gbk
2123618*14630922692Island text2.2289638.727617.5387Neighbours35BLASTN123618.gbk
3149657*17626726611Island text1.3836832.867236.326Neighbours320BLASTN+149657.gbk
436440438611521712Island text1.988341.659644.022Neighbours24BLASTN+364404.gbk
587983491211432281Island text1.6346537.299450.2558Neighbours24BLASTN+879834.gbk
6917817*94070122885Island text1.983533.530625.737Neighbours24BLASTN917817.gbk
71408000*143224524246Island text1.612333.786549.5493Neighbours24BLASTN1408000.gbk
81439775146242622652Island text3.1066941.289520.6453Neighbours24BLASTN+1439775.gbk
91535904*155745921556Island text1.4819231.128430.7894Neighbours24BLASTN+1535904.gbk
101613762*163575821997Island text2.8212937.737521.9585Neighbours35BLASTN+1613762.gbk
111755500183968684187Island text1.6271730.228636.9594Neighbours24BLASTN+1755500.gbk
122183708*221233028623Island text1.5976730.980830.7711Neighbours24BLASTN+2183708.gbk
132220000*224599926000Island text1.9066933.957533.3582Neighbours35BLASTN+2220000.gbk