Pre_GI Island

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n1_4mer:GRV/n1_4mer:RV = (Global Relative Variance of OU patterns) / (Local Relative Variance of OU patterns)

n0_4mer:D = Distance between local and global OU patterns

n0_4mer:PS = Distance between 2 strands of same DNA molecule

Selected loci indicated by large D, increased GRV associated with decreased RV and moderate increase in PS

NC_015848: Mycobacterium canettii CIPT 140010059, complete genome

NCBI: NC_015848

Host Lineage: Mycobacterium canettii; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: The Republic of Djibouti, Africa appears to be an exceptional place in terms of tuberculosis (TB) caused by Mycobacterium canettii, a highly unusual tubercle bacillus with unusual smooth colony morphology (STB) related to the M. tuberculosis complex (MTBC). M. canettii was first isolated from a 20-year-old French farmer suffering from pulmonary tuberculosis by G. Canetti in 1969. Since then, this strain has been isolated on rare occasions from patients who lived or were presumably infected in East Africa. It tends to preferentially affect children and foreigners in the Horn of Africa. M. canettii, a possible ancestor of the MTBC, is found almost exclusively in the Horn of Africa where TB is thought to have emerged about 40 000 years ago, coinciding with the expansion of human population out of Africa. The geographical restriction of M. canettii isolates and contrasting genetic diversity are characteristics compatible with a non-human reservoir. With the larger pan-genome reflecting the ancestral, wider gene pool of tubercle bacilli, their lower virulence and faster growth, especially at temperatures below 37 degrees C, plausibly reflecting broader environmental adaptability, STB strains might thus come nearer to the as-yet-unknown missing link between the obligate pathogen M. tuberculosis and environmental mycobacteria (adapted from PMIDs 20831613 and 23291586). Mycobacteria have an unusual outer membrane approximately 8nm thick, despite being considered Gram-positive. The outer membrane and the mycolic acid-arabinoglactan-peptidoglycan polymer form the cell wall, which constitutes an efficient permeability barrier in conjunction with the cell inner membrane.

Islands with an asterisk (*) contain ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

#StartEndLengthIsland TextGRV_RVDPSNeighboursClusterSub ClusterBLASTNKey Word ConfirmationOther DB ConfirmationDownload Island
148350050998826489Island text1.8086818.826230.5026Neighbours11BLASTN+483500.gbk
21105892*112732621435Island text1.717619.301529.0013Neighbours11BLASTN+IslandViewer 1105892.gbk
31647523167029122769Island text1.4908824.635219.9172Neighbours11BLASTN+1647523.gbk
41708176173271724542Island text1.9786821.533620.8156Neighbours11BLASTN+1708176.gbk
51896660192209125432Island text1.748220.035735.4563Neighbours11BLASTN+1896660.gbk
62381148240458223435Island text1.4421916.701127.683Neighbours11BLASTN+IslandViewer 2381148.gbk
72684275*270528621012Island text1.5111618.493632.775Neighbours11BLASTN2684275.gbk
82859145288297223828Island text1.4994919.582922.92Neighbours11BLASTNIslandViewer 2859145.gbk
93175692319911823427Island text1.4974725.164235.8448Neighbours11BLASTN+IslandViewer 3175692.gbk
103343731336691823188Island text1.5533616.549130.6127Neighbours11BLASTN3343731.gbk
113851230387671725488Island text1.5614919.078322.5241Neighbours11BLASTN+3851230.gbk