Pre_GI Gene

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Host: NC_015848 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_015848:1708176 Mycobacterium canettii CIPT 140010059, complete genome

Host Lineage: Mycobacterium canettii; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: The Republic of Djibouti, Africa appears to be an exceptional place in terms of tuberculosis (TB) caused by Mycobacterium canettii, a highly unusual tubercle bacillus with unusual smooth colony morphology (STB) related to the M. tuberculosis complex (MTBC). M. canettii was first isolated from a 20-year-old French farmer suffering from pulmonary tuberculosis by G. Canetti in 1969. Since then, this strain has been isolated on rare occasions from patients who lived or were presumably infected in East Africa. It tends to preferentially affect children and foreigners in the Horn of Africa. M. canettii, a possible ancestor of the MTBC, is found almost exclusively in the Horn of Africa where TB is thought to have emerged about 40 000 years ago, coinciding with the expansion of human population out of Africa. The geographical restriction of M. canettii isolates and contrasting genetic diversity are characteristics compatible with a non-human reservoir. With the larger pan-genome reflecting the ancestral, wider gene pool of tubercle bacilli, their lower virulence and faster growth, especially at temperatures below 37 degrees C, plausibly reflecting broader environmental adaptability, STB strains might thus come nearer to the as-yet-unknown missing link between the obligate pathogen M. tuberculosis and environmental mycobacteria (adapted from PMIDs 20831613 and 23291586). Mycobacteria have an unusual outer membrane approximately 8nm thick, despite being considered Gram-positive. The outer membrane and the mycolic acid-arabinoglactan-peptidoglycan polymer form the cell wall, which constitutes an efficient permeability barrier in conjunction with the cell inner membrane.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
170817617104282253putative methylmalonyl-CoA mutase large subunit MUTBQuickGO ontologyBLASTP
17104421710744303hypothetical proteinBLASTP
17107411711058318hypothetical proteinBLASTP
171105517120591005putative transport system kinaseQuickGO ontologyBLASTP
171211217134011290putative esterase LIPLQuickGO ontologyBLASTP
17134741714091618putative methyltransferaseQuickGO ontologyBLASTP
17143051714517213hypothetical proteinBLASTP
17145781714976399hypothetical proteinBLASTP
171502117160491029putative glycosyltransferaseQuickGO ontologyBLASTP
17160611716882822hypothetical proteinBLASTP
17170951717994900hypothetical proteinBLASTP
17181671718607441hypothetical proteinBLASTP
17187161719315600hypothetical proteinBLASTP
17194521720117666hypothetical proteinBLASTP
17201141720614501hypothetical proteinBLASTP
17209021721597696hypothetical proteinBLASTP
17215311722034504hypothetical proteinBLASTP
172227017240691800hypothetical proteinBLASTP
17240411724403363hypothetical proteinBLASTP
17243871725268882hypothetical proteinBLASTP
172547017267681299hypothetical proteinBLASTP
172724917282711023GDP-D-mannose dehydratase gmdAQuickGO ontologyBLASTP
17282681729236969putative nucleotide-sugar epimerase epiAQuickGO ontologyBLASTP
17292331729967735hypothetical proteinBLASTP
17299851730773789hypothetical proteinBLASTP
17308081731704897hypothetical proteinBLASTP
173170717327171011putative sugar transferaseQuickGO ontologyBLASTP