Pre_GI Gene

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Host: NC_015848 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_015848:2859145 Mycobacterium canettii CIPT 140010059, complete genome

Host Lineage: Mycobacterium canettii; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: The Republic of Djibouti, Africa appears to be an exceptional place in terms of tuberculosis (TB) caused by Mycobacterium canettii, a highly unusual tubercle bacillus with unusual smooth colony morphology (STB) related to the M. tuberculosis complex (MTBC). M. canettii was first isolated from a 20-year-old French farmer suffering from pulmonary tuberculosis by G. Canetti in 1969. Since then, this strain has been isolated on rare occasions from patients who lived or were presumably infected in East Africa. It tends to preferentially affect children and foreigners in the Horn of Africa. M. canettii, a possible ancestor of the MTBC, is found almost exclusively in the Horn of Africa where TB is thought to have emerged about 40 000 years ago, coinciding with the expansion of human population out of Africa. The geographical restriction of M. canettii isolates and contrasting genetic diversity are characteristics compatible with a non-human reservoir. With the larger pan-genome reflecting the ancestral, wider gene pool of tubercle bacilli, their lower virulence and faster growth, especially at temperatures below 37 degrees C, plausibly reflecting broader environmental adaptability, STB strains might thus come nearer to the as-yet-unknown missing link between the obligate pathogen M. tuberculosis and environmental mycobacteria (adapted from PMIDs 20831613 and 23291586). Mycobacteria have an unusual outer membrane approximately 8nm thick, despite being considered Gram-positive. The outer membrane and the mycolic acid-arabinoglactan-peptidoglycan polymer form the cell wall, which constitutes an efficient permeability barrier in conjunction with the cell inner membrane.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
285914528612292085PE-PGRS family proteinQuickGO ontologyBLASTP
286155928654673909PE-PGRS family proteinQuickGO ontologyBLASTP
286552528688693345putative transcriptional regulatory proteinQuickGO ontologyBLASTP
28689072869206300hypothetical proteinBLASTP
286931528742974983PE-PGRS family proteinQuickGO ontologyBLASTP
28747262875349624hypothetical proteinBLASTP
28753392876091753hypothetical proteinBLASTP
28761442876365222hypothetical proteinBLASTP
28763712876796426hypothetical proteinBLASTP
287681928780001182putative dihydrolipoamide S-acetyltransferase E2 component PDHCQuickGO ontologyBLASTP
287799728790431047putative pyruvate dehydrogenase E1 component subunit beta PDHBQuickGO ontologyBLASTP
287905428801571104putative pyruvate dehydrogenase E1 componentQuickGO ontologyBLASTP
28804162881237822putative citrate PRO-3S-lyase subunit betaQuickGO ontologyBLASTP
28812342881791558putative oxidase regulatory-like proteinQuickGO ontologyBLASTP
288178828829721185putative acyl-CoA dehydrogenase FADE19 MMGCQuickGO ontologyBLASTP