Pre_GI Gene

Some Help

Host: NC_015848 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_015848:2684275 Mycobacterium canettii CIPT 140010059, complete genome

Host Lineage: Mycobacterium canettii; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: The Republic of Djibouti, Africa appears to be an exceptional place in terms of tuberculosis (TB) caused by Mycobacterium canettii, a highly unusual tubercle bacillus with unusual smooth colony morphology (STB) related to the M. tuberculosis complex (MTBC). M. canettii was first isolated from a 20-year-old French farmer suffering from pulmonary tuberculosis by G. Canetti in 1969. Since then, this strain has been isolated on rare occasions from patients who lived or were presumably infected in East Africa. It tends to preferentially affect children and foreigners in the Horn of Africa. M. canettii, a possible ancestor of the MTBC, is found almost exclusively in the Horn of Africa where TB is thought to have emerged about 40 000 years ago, coinciding with the expansion of human population out of Africa. The geographical restriction of M. canettii isolates and contrasting genetic diversity are characteristics compatible with a non-human reservoir. With the larger pan-genome reflecting the ancestral, wider gene pool of tubercle bacilli, their lower virulence and faster growth, especially at temperatures below 37 degrees C, plausibly reflecting broader environmental adaptability, STB strains might thus come nearer to the as-yet-unknown missing link between the obligate pathogen M. tuberculosis and environmental mycobacteria (adapted from PMIDs 20831613 and 23291586). Mycobacteria have an unusual outer membrane approximately 8nm thick, despite being considered Gram-positive. The outer membrane and the mycolic acid-arabinoglactan-peptidoglycan polymer form the cell wall, which constitutes an efficient permeability barrier in conjunction with the cell inner membrane.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
268427526858011527putative phospholipase C 3 PLCCQuickGO ontologyBLASTP
268588426874221539putative membrane-associated phospholipase C 2 PLCBQuickGO ontologyBLASTP
268764026891781539putative membrane-associated phospholipase C 1 PLCAQuickGO ontologyBLASTP
269002726912021176PPE family proteinQuickGO ontologyBLASTP
26914042691694291putative esat-6 like proteinQuickGO ontologyBLASTP
269209126932661176PPE family proteinQuickGO ontologyBLASTP
269369626955191824ppe family proteinQuickGO ontologyBLASTP
269630126981481848PPE family proteinQuickGO ontologyBLASTP
269828626996771392putative glycyl-tRNA synthetase GLYSQuickGO ontologyBLASTP
26998592700266408putative transcriptional regulatory proteinQuickGO ontologyBLASTP
27002632700655393putative ferric uptake regulation protein FURBQuickGO ontologyBLASTP
27007632701191429hypothetical proteinBLASTP
27011912702081891long C50 chain Z-isoprenyl diphosphate synthaseQuickGO ontologyBLASTP
27020742702871798hypothetical proteinBLASTP
270293327043871455putative amidase AMIA2QuickGO ontologyBLASTP
27043842705286903putative GTP-binding protein ERAQuickGO ontologyBLASTP