Pre_GI Gene

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Host: NC_015848 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_015848:2381148 Mycobacterium canettii CIPT 140010059, complete genome

Host Lineage: Mycobacterium canettii; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: The Republic of Djibouti, Africa appears to be an exceptional place in terms of tuberculosis (TB) caused by Mycobacterium canettii, a highly unusual tubercle bacillus with unusual smooth colony morphology (STB) related to the M. tuberculosis complex (MTBC). M. canettii was first isolated from a 20-year-old French farmer suffering from pulmonary tuberculosis by G. Canetti in 1969. Since then, this strain has been isolated on rare occasions from patients who lived or were presumably infected in East Africa. It tends to preferentially affect children and foreigners in the Horn of Africa. M. canettii, a possible ancestor of the MTBC, is found almost exclusively in the Horn of Africa where TB is thought to have emerged about 40 000 years ago, coinciding with the expansion of human population out of Africa. The geographical restriction of M. canettii isolates and contrasting genetic diversity are characteristics compatible with a non-human reservoir. With the larger pan-genome reflecting the ancestral, wider gene pool of tubercle bacilli, their lower virulence and faster growth, especially at temperatures below 37 degrees C, plausibly reflecting broader environmental adaptability, STB strains might thus come nearer to the as-yet-unknown missing link between the obligate pathogen M. tuberculosis and environmental mycobacteria (adapted from PMIDs 20831613 and 23291586). Mycobacteria have an unusual outer membrane approximately 8nm thick, despite being considered Gram-positive. The outer membrane and the mycolic acid-arabinoglactan-peptidoglycan polymer form the cell wall, which constitutes an efficient permeability barrier in conjunction with the cell inner membrane.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
238114823826111464hypothetical proteinBLASTP
23831742383488315hypothetical protein
238347023854401971hypothetical proteinBLASTP
23854212385984564putative lipoprotein lppJQuickGO ontologyBLASTP
238682723888001974hypothetical proteinBLASTP
238940723912331827hypothetical proteinBLASTP
239146823924781011integrase catalytic subunitQuickGO ontologyBLASTP
23927492393423675putative transmembrane proteinQuickGO ontology
239352523956782154hypothetical proteinBLASTP
23956752396619945hypothetical protein
23966122397607996hypothetical protein
23978182398645828integrase catalytic subunitQuickGO ontologyBLASTP
23991202399425306hypothetical proteinBLASTP
23994042400009606hypothetical proteinBLASTP
24001362400432297transposase IS21 family proteinQuickGO ontologyBLASTP
24004412401268828integrase catalytic subunitQuickGO ontologyBLASTP
240143024025571128putative dipeptidase PepEQuickGO ontologyBLASTP
240260624038441239putative 5-3 exonucleaseQuickGO ontologyBLASTP
24038482404582735hypothetical proteinBLASTP