Pre_GI Gene

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Host: NC_015425 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_015425:641000 Clostridium botulinum BKT015925 chromosome, complete genome

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin. Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
6411336429801848spore coat proteinQuickGO ontologyBLASTP
643052644023972L-lactate dehydrogenaseQuickGO ontologyBLASTP
644334644990657transcriptional activator TenAQuickGO ontologyBLASTP
645008645595588putative proton-coupled thiamine transporter YuaJQuickGO ontologyBLASTP
645887646396510GNAT family acetyltransferaseQuickGO ontologyBLASTP
646500647033534putative phosphoesteraseQuickGO ontology
647072647518447phosphotransferase system mannitolfructose-specific IIA domainQuickGO ontologyBLASTP
647695648672978hypothetical proteinBLASTP
6486836498281146hypothetical proteinBLASTP
6498396525142676hypothetical proteinBLASTP
652519653220702NPQTN cell wall surface anchor proteinQuickGO ontologyBLASTP
653265654191927iron III dicitrate-binding periplasmic proteinQuickGO ontologyBLASTP
654198655196999iron compound ABC transporter permeaseQuickGO ontologyBLASTP
655198656010813ferric enterobactin transport ATP-binding protein fepCQuickGO ontologyBLASTP
656014656628615sortaseQuickGO ontologyBLASTP
6567256584011677multidrug resistance protein 1QuickGO ontologyBLASTP
6584186600701653putative ABC transporterQuickGO ontologyBLASTP
660238660543306PTS system transporter subunit IIBQuickGO ontologyBLASTP
660716661108393hypothetical protein
6613026630381737DNAk proteinQuickGO ontologyBLASTP
6630636642141152hypothetical proteinBLASTP