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Query: NC_015425:641000:660238 Clostridium botulinum BKT015925 chromosome, complete genome

Start: 660238, End: 660543, Length: 306

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin. Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_008593:609723:611561611561611848288Clostridium novyi NT, complete genomePTS system, IIB component5e-38155
NC_008800:1459015:148022214802221480509288Yersinia enterocolitica subsp. enterocolitica 8081 chromosome,phosphotransferase enzyme II, B component1e-1272
NC_015224:3225000:322552132255213225808288Yersinia enterocolitica subsp. palearctica 105.5R(r) chromosome,phosphotransferase enzyme II, B component1e-1272
NC_004431:279868:307212307212307499288Escherichia coli CFT073, complete genomehypothetical protein1e-1271.6
NC_007712:3511500:351721135172113517483273Sodalis glossinidius str. 'morsitans', complete genomeputative PTS system IIB component4e-1270.1
NC_012467:1997484:199884319988431999127285Streptococcus pneumoniae P1031, complete genomephosphotransferase system, galactitol-specific IIB component9e-1268.9
NC_013198:394000:405249405249405530282Lactobacillus rhamnosus GG, complete genomePTS system, lactose/cellobiose/mannitol/pentitol/galactitol/fructose/L -ascorbate-specific EIIB component (lipoprotein, SgaB, SgaT)6e-1166.2
NC_012926:140000:176952176952177236285Streptococcus suis BM407 chromosome, complete genomePTS system lactose/cellobiose-specific family transporter subunit IIB2e-1064.7
NC_013411:2975364:298698829869882987272285Geobacillus sp. Y412MC61, complete genomephosphotransferase system lactose/cellobiose-specific IIB subunit8e-1062.4
NC_014915:2092678:212691921269192127203285Geobacillus sp. Y412MC52 chromosome, complete genomephosphotransferase system lactose/cellobiose-specific IIB subunit8e-1062.4
NC_014228:2812000:283069528306952830982288Xenorhabdus nematophila ATCC 19061, complete genomeputative sugar phosphotransferase component II B1e-0962
NC_009648:1914621:192832219283221928588267Klebsiella pneumoniae subsp. pneumoniae MGH 78578, complete genomePTS family protein II component2e-0960.8
NC_012731:2650603:266430226643022664568267Klebsiella pneumoniae NTUH-K2044 chromosome, complete genomeascorbate-specific PTS family enzyme IIB component2e-0960.8
NC_016845:2691129:270484927048492705115267Klebsiella pneumoniae subsp. pneumoniae HS11286 chromosome,PTS family protein II component2e-0960.8
NC_020181:969599:975575975575975841267Enterobacter aerogenes EA1509E, complete genomeFIG01225319: hypothetical protein2e-0960.8
NC_015663:4447984:446125044612504461516267Enterobacter aerogenes KCTC 2190 chromosome, complete genomeascorbate-specific PTS family enzyme IIB component2e-0960.8
NC_013508:3188978:319260131926013192888288Edwardsiella tarda EIB202, complete genomephosphotransferase enzyme II, B component4e-0960.1
NC_009053:1942973:194776319477631948035273Actinobacillus pleuropneumoniae L20, complete genomePhosphotransferase system, galactitol-specific IIB component6e-0959.3
NC_013850:2685835:269188326918832692149267Klebsiella variicola At-22 chromosome, complete genomephosphotransferase system lactose/cellobiose-specific IIB subunit5e-0856.6
NC_014831:2201246:221381922138192214118300Thermaerobacter marianensis DSM 12885 chromosome, complete genomephosphotransferase system lactose/cellobiose-specific IIB subunit1e-0755.5
NC_003210:2721559:272288427228842723156273Listeria monocytogenes EGD-e, complete genomehypothetical protein7e-0752.8
NC_004432:936500:943651943651943932282Mycoplasma penetrans HF-2, complete genomePTS system enzyme IIB component4e-0650.1