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Query: NC_015425:641000:648683 Clostridium botulinum BKT015925 chromosome, complete genome

Start: 648683, End: 649828, Length: 1146

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin. Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_015425:641000:647695647695648672978Clostridium botulinum BKT015925 chromosome, complete genomehypothetical protein1e-76287
NC_015425:641000:6498396498396525142676Clostridium botulinum BKT015925 chromosome, complete genomehypothetical protein2e-65249
NC_008593:609723:6185476185476212672721Clostridium novyi NT, complete genomeLeucine Rich Repeat domain protein5e-34145
NC_008593:609723:6213566213566263835028Clostridium novyi NT, complete genomehypothetical protein2e-1790.1
NC_015425:641000:652519652519653220702Clostridium botulinum BKT015925 chromosome, complete genomeNPQTN cell wall surface anchor protein7e-1478.6