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Query: NC_015425:641000:645008 Clostridium botulinum BKT015925 chromosome, complete genome

Start: 645008, End: 645595, Length: 588

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin. Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017294:1385576:138775413877541388416663Candidatus Arthromitus sp. SFB-mouse-Yit, complete genomeputative proton-coupled thiamine transporter YuaJ2e-40165
NC_009617:68779:847138471385390678Clostridium beijerinckii NCIMB 8052 chromosome, complete genomeproton-coupled thiamine transporter YuaJ3e-25114
NC_020291:79502:849128491285589678Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomeputative proton-coupled thiamine transporter YuaJ2e-21102
NC_015437:227420:227420227420228061642Selenomonas sputigena ATCC 35185 chromosome, complete genomeproton-coupled thiamine transporter YuaJ3e-1891.7
NC_011999:1567818:156995515699551570566612Macrococcus caseolyticus JCSC5402, complete genomehypothetical protein8e-1890.1
NC_018664:1729794:175075417507541751317564Clostridium acidurici 9a chromosome, complete genomethiamine transporter YuaJ5e-1580.9
NC_014976:1174430:118807611880761188654579Bacillus subtilis BSn5 chromosome, complete genomethiamin permease3e-1374.7