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Query: NC_015425:641000:645887 Clostridium botulinum BKT015925 chromosome, complete genome

Start: 645887, End: 646396, Length: 510

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin. Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_010674:658596:673380673380673895516Clostridium botulinum B str. Eklund 17B, complete genomeGnaT-family acetyltransferase1e-35149
NC_014910:2585747:259558825955882596499912Alicycliphilus denitrificans BC chromosome, complete genomegcn5-related n-acetyltransferase2e-35148
NC_010723:622928:638577638577639092516Clostridium botulinum E3 str. Alaska E43, complete genomeGnaT-family acetyltransferase5e-34143
NC_015410:2698572:270645827064582707378921Pseudomonas mendocina NK-01 chromosome, complete genomeacetyltransferase4e-33140
NC_004129:3965947:3973732397373239748711140Pseudomonas fluorescens Pf-5, complete genomeacetyltransferase, GNAT family family1e-32138
NC_016048:522637:542125542125542742618Oscillibacter valericigenes Sjm18-20, complete genomeputative acetyltransferase1e-22105
NC_011772:2860000:287941728794172879956540Bacillus cereus G9842, complete genomebifunctional AAC/APH4e-0753.9
NC_013406:2207520:221452822145282215067540Paenibacillus sp. Y412MC10 chromosome, complete genomeGCN5-like N-acetyltransferase8e-0753.1
NC_016582:9664000:967312196731219673612492Streptomyces bingchenggensis BCW-1 chromosome, complete genomeN-acetyltransferase GCN51e-0652.4
NC_017208:2942554:296167829616782962217540Bacillus thuringiensis serovar chinensis CT-43 chromosome, complete2''-aminoglycoside phosphotransferase2e-0652
NC_011773:2782465:279979627997962800329534Bacillus cereus AH820 chromosome, complete genomeGNAT family acetyltransferase2e-0651.6
NC_016779:2693790:271117727111772711710534Bacillus cereus F837/76 chromosome, complete genomeisochorismatase5e-0650.4
NC_008600:2792584:280981728098172810350534Bacillus thuringiensis str. Al Hakam, complete genomeacetyltransferase, GNAT family5e-0650.4