Pre_GI: BLASTP Hits

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Query: NC_016913:917500:935322 Rickettsia rickettsii str. Brazil chromosome, complete genome

Start: 935322, End: 935504, Length: 183

Host Lineage: Rickettsia rickettsii; Rickettsia; Rickettsiaceae; Rickettsiales; Proteobacteria; Bacteria

General Information: This genus, like other Rickettsial organisms such as Neorickettsia and Anaplasma, are obligate intracellular pathogens and is composed of two groups, the spotted fever group, and the typhus group. The latter is composed of two organisms, Rickettsia prowazekii and Rickettsia typhi. The bacteria are transmitted via an insect, usually a tick, to a host organism, in this case humans, where they target endothelial cells and sometimes macrophages. They attach via an adhesin, rickettsial outer membrane protein A, and are internalized where they persist as cytoplasmically free organisms. This organism was first identified by Dr. Howard Rickets as the causative agent of Rocky Mountain Spotted Fever, which was originally named for its geographic distribution at the time, it is now known to be widespread throughout the North American continent. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. It is passed to the human host from a tick bite, and the tick acts as both a natural reservoir and a vector for disease transmission. Once the organism is endocytosed by the host cell, it quickly escapes the phagozome, and replicates intracellularly, causing cell death and tissue damage. The disease is characterized by a spotted rash and has a high mortality rate if left untreated.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_016914:231324:233697233697233879183Rickettsia rickettsii str. Hino chromosome, complete genomehypothetical protein5e-28122
NC_016911:232481:233558233558233740183Rickettsia rickettsii str. Hauke chromosome, complete genomehypothetical protein5e-28122
NC_016909:230000:233470233470233652183Rickettsia rickettsii str. Arizona chromosome, complete genomehypothetical protein5e-28122
NC_009882:232400:233516233516233698183Rickettsia rickettsii str. 'Sheila Smith', complete genomehypothetical protein5e-28122
NC_010263:232482:233610233610233792183Rickettsia rickettsii str. Iowa, complete genomehypothetical protein5e-28122
NC_003103:225956:229730229730230050321Rickettsia conorii str. Malish 7, complete genomehypothetical protein2e-24110
NC_016930:228000:231541231541231729189Rickettsia philipii str. 364D chromosome, complete genomehypothetical protein2e-24110
NC_015866:233448:235812235812236000189Rickettsia heilongjiangensis 054 chromosome, complete genomehypothetical protein1e-23108
NC_009900:231983:236401236401236805405Rickettsia massiliae MTU5, complete genome1e-2098.6