Pre_GI Gene

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Host: NC_009882 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_009882:232400 Rickettsia rickettsii str. 'Sheila Smith', complete genome

Host Lineage: Rickettsia rickettsii; Rickettsia; Rickettsiaceae; Rickettsiales; Proteobacteria; Bacteria

General Information: This strain was isolated from from a patient with Rocky Mountain spotted fever. Causative agent for Rocky Mountain Spotted Fever. This genus, like other Rickettsial organisms such as Neorickettsia and Anaplasma, are obligate intracellular pathogens and is composed of two groups, the spotted fever group, and the typhus group. The latter is composed of two organisms, Rickettsia prowazekii and Rickettsia typhi. The bacteria are transmitted via an insect, usually a tick, to a host organism, in this case humans, where they target endothelial cells and sometimes macrophages. They attach via an adhesin, rickettsial outer membrane protein A, and are internalized where they persist as cytoplasmically free organisms. Rickettsia rickettsii was first identified by Dr. Howard Rickets as the causative agent of Rocky Mountain Spotted Fever, which was originally named for its geographic distribution at the time, it is now known to be widespread throughout the North American continent. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. It is passed to the human host from a tick bite, and the tick acts as both a natural reservoir and a vector for disease transmission. Once the organism is endocytosed by the host cell, it quickly escapes the phagozome, and replicates intracellularly, causing cell death and tissue damage. The disease is characterized by a spotted rash and has a high mortality rate if left untreated.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
232400232537138hypothetical proteinBLASTP
232567232908342Ankyrin repeatQuickGO ontologyBLASTP
232970233101132Ankyrin repeatQuickGO ontologyBLASTP
233516233698183hypothetical proteinBLASTP
234023234208186hypothetical proteinBLASTP
2342622354611200protonsodium-glutamate symport proteinQuickGO ontologyBLASTP
235500235814315Periplasmic divalent cation tolerance proteinQuickGO ontologyBLASTP
235817236233417hypothetical proteinBLASTP
2364042375911188dihydrolipoamide acetyltransferaseQuickGO ontologyBLASTP
237606237758153alpha-ketoglutarate decarboxylaseQuickGO ontologyBLASTP
23775524054127872-oxoglutarate dehydrogenase e1 componentQuickGO ontologyBLASTP
2406772421671491thermostable carboxypeptidaseQuickGO ontologyBLASTP
2422332438701638DNA repair protein RecNQuickGO ontologyBLASTP
243878244633756hypothetical proteinBLASTP
24491224500493hypothetical proteinBLASTP
244994245095102hypothetical proteinBLASTP
2451742462951122dnaJ proteinQuickGO ontologyBLASTP
2464242483071884molecular chaperone DnaKQuickGO ontologyBLASTP
2483692498621494heat shock proteaseQuickGO ontologyBLASTP