Pre_GI Gene

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Host: NC_016914 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_016914:231324 Rickettsia rickettsii str. Hino chromosome, complete genome

Host Lineage: Rickettsia rickettsii; Rickettsia; Rickettsiaceae; Rickettsiales; Proteobacteria; Bacteria

General Information: This genus, like other Rickettsial organisms such as Neorickettsia and Anaplasma, are obligate intracellular pathogens and is composed of two groups, the spotted fever group, and the typhus group. The latter is composed of two organisms, Rickettsia prowazekii and Rickettsia typhi. The bacteria are transmitted via an insect, usually a tick, to a host organism, in this case humans, where they target endothelial cells and sometimes macrophages. They attach via an adhesin, rickettsial outer membrane protein A, and are internalized where they persist as cytoplasmically free organisms. This organism was first identified by Dr. Howard Rickets as the causative agent of Rocky Mountain Spotted Fever, which was originally named for its geographic distribution at the time, it is now known to be widespread throughout the North American continent. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. It is passed to the human host from a tick bite, and the tick acts as both a natural reservoir and a vector for disease transmission. Once the organism is endocytosed by the host cell, it quickly escapes the phagozome, and replicates intracellularly, causing cell death and tissue damage. The disease is characterized by a spotted rash and has a high mortality rate if left untreated.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
2313242325261203coproporphyrinogen III oxidaseQuickGO ontologyBLASTP
23262023271899hypothetical protein
232748233089342hypothetical proteinBLASTP
233151233282132hypothetical proteinBLASTP
233697233879183hypothetical proteinBLASTP
234204234392189hypothetical proteinBLASTP
2344432356421200protonsodium-glutamate symport proteinQuickGO ontologyBLASTP
235681235995315divalent cation tolerance proteinQuickGO ontologyBLASTP
2359982364144176-carboxy-5678-tetrahydropterin synthaseQuickGO ontologyBLASTP
2365852377721188dihydrolipoamide succinyltransferaseQuickGO ontologyBLASTP
237787237939153hypothetical proteinBLASTP
23793624072227872-oxoglutarate dehydrogenase E1 componentQuickGO ontologyBLASTP
2408582423481491thermostable carboxypeptidaseQuickGO ontologyBLASTP
2424142440511638DNA repair protein RecNQuickGO ontologyBLASTP
244059244814756ComL family lipoproteinQuickGO ontologyBLASTP
245093245272180cation transport regulatorQuickGO ontologyBLASTP
2453512464721122chaperone protein DnaJQuickGO ontologyBLASTP
2466012484841884molecular chaperone DnaKQuickGO ontologyBLASTP
2485462500391494endopeptidaseQuickGO ontologyBLASTP
250785251063279hypothetical proteinBLASTP
251204251545342hypothetical proteinBLASTP