Pre_GI Gene

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Host: NC_016911 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_016911:232481 Rickettsia rickettsii str. Hauke chromosome, complete genome

Host Lineage: Rickettsia rickettsii; Rickettsia; Rickettsiaceae; Rickettsiales; Proteobacteria; Bacteria

General Information: This genus, like other Rickettsial organisms such as Neorickettsia and Anaplasma, are obligate intracellular pathogens and is composed of two groups, the spotted fever group, and the typhus group. The latter is composed of two organisms, Rickettsia prowazekii and Rickettsia typhi. The bacteria are transmitted via an insect, usually a tick, to a host organism, in this case humans, where they target endothelial cells and sometimes macrophages. They attach via an adhesin, rickettsial outer membrane protein A, and are internalized where they persist as cytoplasmically free organisms. This organism was first identified by Dr. Howard Rickets as the causative agent of Rocky Mountain Spotted Fever, which was originally named for its geographic distribution at the time, it is now known to be widespread throughout the North American continent. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. It is passed to the human host from a tick bite, and the tick acts as both a natural reservoir and a vector for disease transmission. Once the organism is endocytosed by the host cell, it quickly escapes the phagozome, and replicates intracellularly, causing cell death and tissue damage. The disease is characterized by a spotted rash and has a high mortality rate if left untreated.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
23248123257999hypothetical protein
232609232950342hypothetical proteinBLASTP
233012233143132hypothetical proteinBLASTP
233558233740183hypothetical proteinBLASTP
234065234250186hypothetical proteinBLASTP
2343042355031200protonsodium-glutamate symport proteinQuickGO ontologyBLASTP
235542235856315divalent cation tolerance proteinQuickGO ontologyBLASTP
2358592362754176-carboxy-5678-tetrahydropterin synthaseQuickGO ontologyBLASTP
2364462376331188dihydrolipoamide succinyltransferaseQuickGO ontologyBLASTP
237648237800153hypothetical proteinBLASTP
23779724058327872-oxoglutarate dehydrogenase E1 componentQuickGO ontologyBLASTP
2407192422091491thermostable carboxypeptidaseQuickGO ontologyBLASTP
2422752439121638DNA repair protein RecNQuickGO ontologyBLASTP
243920244675756ComL family lipoproteinQuickGO ontologyBLASTP
244954245133180cation transport regulatorQuickGO ontologyBLASTP
2452122463331122chaperone protein DnaJQuickGO ontologyBLASTP
2464622483451884molecular chaperone DnaKQuickGO ontologyBLASTP
2484072499001494endopeptidaseQuickGO ontologyBLASTP