Pre_GI Gene

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Host: NC_005945 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_005945:1008000 Bacillus anthracis str. Sterne, complete genome

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This strain carries the anthrax toxin plasmid pXO1 but not the capsule plasmid pXO2 and is therefore avirulent but toxigenic. It is the counterpart to the Pasteur strain that carries pXO2 but not pXO1. This strain is often used for vaccine development. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
10080221008999978glyoxylase family proteinQuickGO ontologyBLASTP
100922310103351113TPR domain proteinQuickGO ontologyBLASTP
10106911011566876hydrolase alphabeta fold familyQuickGO ontologyBLASTP
10116471011847201hypothetical proteinBLASTP
10120211012872852hypothetical proteinBLASTP
10132321013510279DNA-binding proteinQuickGO ontologyBLASTP
10134801013680201hypothetical proteinBLASTP
10137781014338561glycerol uptake operon antiterminator regulatory proteinQuickGO ontologyBLASTP
10145521015388837glycerol uptake facilitator proteinQuickGO ontologyBLASTP
101540210168921491glycerol kinaseQuickGO ontologyBLASTP
101702610187081683glycerol-3-phosphate dehydrogenase aerobicQuickGO ontologyBLASTP
10189061019115210hypothetical proteinBLASTP
10195181019928411hypothetical proteinBLASTP
10200961020716621RNA polymerase sigma C factorQuickGO ontologyBLASTP
10207211021128408lineage-specific thermal regulator proteinQuickGO ontologyBLASTP
102113610223861251cell division protein FtsWRodASpoVE familyQuickGO ontologyBLASTP
10224441022929486transcriptional regulator MarR familyQuickGO ontologyBLASTP
10232141023579366hypothetical proteinBLASTP
102374110251321392major facilitator family transporterQuickGO ontologyBLASTP
102515510266031449drug resistance transporter EmrBQacA familyQuickGO ontologyBLASTP