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Query: NC_005945:1008000:1019518 Bacillus anthracis str. Sterne, complete genome

Start: 1019518, End: 1019928, Length: 411

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This strain carries the anthrax toxin plasmid pXO1 but not the capsule plasmid pXO2 and is therefore avirulent but toxigenic. It is the counterpart to the Pasteur strain that carries pXO2 but not pXO1. This strain is often used for vaccine development. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_012659:1008028:101952510195251019935411Bacillus anthracis str. A0248, complete genomehypothetical protein2e-64243
NC_011773:1050000:106183010618301062240411Bacillus cereus AH820 chromosome, complete genomehypothetical protein2e-64243
NC_003997:1007139:101962510196251020035411Bacillus anthracis str. Ames, complete genomehypothetical protein2e-64243
NC_007530:1007140:101962510196251020035411Bacillus anthracis str. 'Ames Ancestor', complete genomehypothetical protein2e-64243
NC_017200:1157835:117265411726541173064411Bacillus thuringiensis serovar finitimus YBT-020 chromosome,hypothetical protein9e-63238
NC_016779:991298:100066110006611001071411Bacillus cereus F837/76 chromosome, complete genomehypothetical protein1e-54211
NC_008600:1042477:105409110540911054513423Bacillus thuringiensis str. Al Hakam, complete genomehypothetical protein1e-54211
NC_005957:1037205:104834710483471048604258Bacillus thuringiensis serovar konkukian str. 97-27, completehypothetical protein5e-35145
NC_005957:1037205:104818110481811048375195Bacillus thuringiensis serovar konkukian str. 97-27, completehypothetical protein2e-1374.7
NC_011969:1084000:109424710942471094414168Bacillus cereus Q1 chromosome, complete genomehypothetical protein4e-0650.4