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Query: NC_005945:1008000:1013480 Bacillus anthracis str. Sterne, complete genome

Start: 1013480, End: 1013680, Length: 201

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This strain carries the anthrax toxin plasmid pXO1 but not the capsule plasmid pXO2 and is therefore avirulent but toxigenic. It is the counterpart to the Pasteur strain that carries pXO2 but not pXO1. This strain is often used for vaccine development. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_012659:1008028:101323810132381013687450Bacillus anthracis str. A0248, complete genomehypothetical protein4e-29126
NC_007530:1007140:101333810133381013787450Bacillus anthracis str. 'Ames Ancestor', complete genomedna-binding protein4e-29126
NC_003997:1007139:101357210135721013787216Bacillus anthracis str. Ames, complete genomehypothetical protein8e-28122
NC_007530:1007140:101357210135721013787216Bacillus anthracis str. 'Ames Ancestor', complete genomehypothetical protein8e-28122
NC_011773:1050000:105554110555411055990450Bacillus cereus AH820 chromosome, complete genomehypothetical protein3e-25113
NC_017208:1050414:105646110564611056910450Bacillus thuringiensis serovar chinensis CT-43 chromosome, completetranscriptional repressor4e-25113
NC_010184:1017000:102191410219141022363450Bacillus weihenstephanensis KBAB4, complete genometranscriptional regulator, XRE family2e-24110
NC_011969:1084000:108843010884301088648219Bacillus cereus Q1 chromosome, complete genometranscriptional repressor2e-24110
NC_005957:1037205:104193210419321042381450Bacillus thuringiensis serovar konkukian str. 97-27, completepossible transcriptional regulator; possible DNA-binding protein1e-23108
NC_011772:1011220:101541510154151015864450Bacillus cereus G9842, complete genomehypothetical protein1e-23108
NC_004722:1008500:101368010136801014129450Bacillus cereus ATCC 14579, complete genomeTranscriptional repressor9e-24108
NC_011725:1032500:103773410377341038183450Bacillus cereus B4264 chromosome, complete genomehypothetical protein2e-22104
NC_016779:991298:994401994401994850450Bacillus cereus F837/76 chromosome, complete genomeXRE family transcriptional regulator3e-22103
NC_014171:1018338:102372210237221023880159Bacillus thuringiensis BMB171 chromosome, complete genometranscriptional repressor1e-1684.7
NC_004193:2921103:293865229386522939191540Oceanobacillus iheyensis HTE831, complete genomehypothetical protein1e-0755.1
NC_009328:3241166:324657732465773246852276Geobacillus thermodenitrificans NG80-2 chromosome, complete genomehypothetical protein4e-0753.5