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Query: NC_005945:1008000:1011647 Bacillus anthracis str. Sterne, complete genome

Start: 1011647, End: 1011847, Length: 201

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This strain carries the anthrax toxin plasmid pXO1 but not the capsule plasmid pXO2 and is therefore avirulent but toxigenic. It is the counterpart to the Pasteur strain that carries pXO2 but not pXO1. This strain is often used for vaccine development. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017200:1157835:116377411637741163974201Bacillus thuringiensis serovar finitimus YBT-020 chromosome,signal peptidase I5e-31132
NC_016779:991298:992817992817993017201Bacillus cereus F837/76 chromosome, complete genomehypothetical protein5e-31132
NC_011969:1084000:108501310850131085213201Bacillus cereus Q1 chromosome, complete genomehypothetical protein5e-31132
NC_006274:1040836:104344210434421043642201Bacillus cereus E33L, complete genomehypothetical protein5e-31132
NC_003997:1007139:101175210117521011952201Bacillus anthracis str. Ames, complete genomehypothetical protein5e-31132
NC_007530:1007140:101175310117531011953201Bacillus anthracis str. 'Ames Ancestor', complete genomehypothetical protein5e-31132
NC_005957:1037205:103816110381611038361201Bacillus thuringiensis serovar konkukian str. 97-27, completehypothetical protein5e-31132
NC_010184:1017000:101816710181671018367201Bacillus weihenstephanensis KBAB4, complete genomehypothetical protein1e-29128
NC_004722:1008500:100954710095471009747201Bacillus cereus ATCC 14579, complete genomehypothetical protein2e-29127
NC_011725:1032500:103359010335901033790201Bacillus cereus B4264 chromosome, complete genomehypothetical protein2e-29127
NC_012659:1008028:101171310117131011853141Bacillus anthracis str. A0248, complete genomehypothetical protein8e-1992.4
NC_011773:1050000:105401610540161054156141Bacillus cereus AH820 chromosome, complete genomehypothetical protein8e-1992.4
NC_017208:1050414:105140410514041051544141Bacillus thuringiensis serovar chinensis CT-43 chromosome, completehypothetical protein1e-1788.2
NC_014171:1018338:101935210193521019492141Bacillus thuringiensis BMB171 chromosome, complete genomehypothetical protein1e-1788.2
NC_011772:1011220:101223110122311012371141Bacillus cereus G9842, complete genomehypothetical protein1e-1788.2
NC_014915:595569:621498621498621686189Geobacillus sp. Y412MC52 chromosome, complete genomehypothetical protein2e-1167.4
NC_013411:1454465:148155314815531481741189Geobacillus sp. Y412MC61, complete genomehypothetical protein2e-1167.4