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Query: NC_005945:1008000:1012021 Bacillus anthracis str. Sterne, complete genome

Start: 1012021, End: 1012872, Length: 852

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This strain carries the anthrax toxin plasmid pXO1 but not the capsule plasmid pXO2 and is therefore avirulent but toxigenic. It is the counterpart to the Pasteur strain that carries pXO2 but not pXO1. This strain is often used for vaccine development. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_016779:991298:993190993190994041852Bacillus cereus F837/76 chromosome, complete genomehypothetical protein4e-167587
NC_008600:1042477:104659310465931047483891Bacillus thuringiensis str. Al Hakam, complete genomehypothetical protein4e-167587
NC_005957:1037205:103853710385371039388852Bacillus thuringiensis serovar konkukian str. 97-27, completehypothetical protein4e-167587
NC_006274:1040836:104381610438161044667852Bacillus cereus E33L, complete genomehypothetical protein4e-167587
NC_011773:1050000:105433010543301055181852Bacillus cereus AH820 chromosome, complete genomehypothetical protein4e-167587
NC_012659:1008028:101202710120271012878852Bacillus anthracis str. A0248, complete genomehypothetical protein4e-167587
NC_011969:1084000:108538710853871086238852Bacillus cereus Q1 chromosome, complete genomehypothetical protein2e-166584
NC_017200:1157835:116414711641471164998852Bacillus thuringiensis serovar finitimus YBT-020 chromosome,hypothetical protein2e-165581
NC_011772:1011220:101256610125661013417852Bacillus cereus G9842, complete genomehypothetical protein2e-164578
NC_004722:1008500:100996210099621010813852Bacillus cereus ATCC 14579, complete genomeIG hypothetical 180632e-164578
NC_011725:1032500:103400510340051034856852Bacillus cereus B4264 chromosome, complete genomehypothetical protein2e-164578
NC_014171:1018338:101970810197081020559852Bacillus thuringiensis BMB171 chromosome, complete genomehypothetical protein2e-164578
NC_017208:1050414:105176010517601052611852Bacillus thuringiensis serovar chinensis CT-43 chromosome, completehypothetical protein2e-164578
NC_010184:1017000:101858110185811019432852Bacillus weihenstephanensis KBAB4, complete genomeIG hypothetical 180633e-163573
NC_007530:1007140:101217810121781012978801Bacillus anthracis str. 'Ames Ancestor', complete genomehypothetical protein3e-156550
NC_003997:1007139:101217710121771012977801Bacillus anthracis str. Ames, complete genomehypothetical protein3e-156550
NC_013406:5954472:596296259629625963780819Paenibacillus sp. Y412MC10 chromosome, complete genomehypothetical protein3e-114411
NC_011898:351792:370295370295371209915Clostridium cellulolyticum H10, complete genomehypothetical protein1e-30133
NC_015589:2555000:256212425621242562936813Desulfotomaculum ruminis DSM 2154 chromosome, complete genomehypothetical protein9e-1064.3