Pre_GI Gene

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Host: NC_004088 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_004088:3186954 Yersinia pestis KIM, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
318695431886541701PTS system fructose-specific IIBC transport proteinQuickGO ontologyBLASTP
318866931896079391-phosphofructokinaseQuickGO ontologyBLASTP
318960431907371134PTS system fructose-specific IIAfpr componentQuickGO ontologyBLASTP
31909183191454537hypothetical proteinBLASTP
31915673192565999permeaseQuickGO ontologyBLASTP
319260131941751575ABC transporterQuickGO ontologyBLASTP
319428431953721089permeaseQuickGO ontologyBLASTP
31954963196248753ribose 5-phosphate isomerase AQuickGO ontologyBLASTP
319622631977791554xylulose kinaseQuickGO ontologyBLASTP
319778331992791497succinate-semialdehyde dehydrogenaseQuickGO ontologyBLASTP
319963132007731143hypothetical proteinBLASTP
32007703201735966dehydrogenaseQuickGO ontologyBLASTP
320174632025618163-oxoacyl-acyl-carrier-protein reductaseQuickGO ontologyBLASTP
32025393202913375hypothetical proteinBLASTP
32026303202884255hypothetical proteinBLASTP
320325932045031245tryptophan-specific transport proteinQuickGO ontologyBLASTP
32045383205179642elongation factor PQuickGO ontologyBLASTP
320531932065121194mannonate dehydrataseQuickGO ontologyBLASTP
320709732085691473oxidoreductaseQuickGO ontologyBLASTP
32087133209513801regulator for uxu operonQuickGO ontologyBLASTP