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Query: NC_012563:2680246:2681387 Clostridium botulinum A2 str. Kyoto, complete genome

Start: 2681387, End: 2681866, Length: 480

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain was isolated from a case of infant botulism in Kyoto, Japan in 1978. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_010723:915697:920387920387920896510Clostridium botulinum E3 str. Alaska E43, complete genomehypothetical protein4e-25113
NC_017179:1683199:170052717005271701006480Clostridium difficile BI1, complete genomehypothetical protein1e-2098.6
NC_013315:1679000:169251216925121692991480Clostridium difficile CD196 chromosome, complete genomehypothetical protein1e-2098.6
NC_010001:986500:100821210082121008709498Clostridium phytofermentans ISDg, complete genomehypothetical protein4e-1684
NC_010001:3614314:363920136392013639698498Clostridium phytofermentans ISDg, complete genomehypothetical protein1e-1479
NC_015275:911999:927979927979928527549Clostridium lentocellum DSM 5427 chromosome, complete genomeSigma-70 region 4 type 21e-0858.9
NC_009253:2819000:283577528357752836296522Desulfotomaculum reducens MI-1 chromosome, complete genomehypothetical protein1e-0858.9
NC_009253:1265474:127831912783191278855537Desulfotomaculum reducens MI-1 chromosome, complete genomehypothetical protein1e-0755.8