Pre_GI: BLASTP Hits

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Query: NC_010520:3526883:3540719 Clostridium botulinum A3 str. Loch Maree, complete genome

Start: 3540719, End: 3540796, Length: 78

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum A3 str. Loch Maree was isolated from duck liver paste during a botulism outbreak at a hotel in the Scottish highlands in 1922. This was the first and worst outbreak of botulism in the United Kingdom (UK). This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_010520:35845:47457474574753478Clostridium botulinum A3 str. Loch Maree, complete genometRNA-Lys3e-0650.4
NC_010520:35845:53996539965407378Clostridium botulinum A3 str. Loch Maree, complete genometRNA-Lys3e-0650.4
NC_010516:42475:53398533985347578Clostridium botulinum B1 str. Okra, complete genometRNA-Lys3e-0650.4
NC_012563:36000:47663476634774078Clostridium botulinum A2 str. Kyoto, complete genometRNA-Lys3e-0650.4
NC_012563:36000:54221542215429878Clostridium botulinum A2 str. Kyoto, complete genometRNA-Lys3e-0650.4
NC_010516:42475:60005600056008278Clostridium botulinum B1 str. Okra, complete genometRNA-Lys3e-0650.4
NC_010520:3526883:35414623541462354153978Clostridium botulinum A3 str. Loch Maree, complete genometRNA-Lys3e-0650.4