Pre_GI Gene

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Host: NC_010520 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_010520:35845 Clostridium botulinum A3 str. Loch Maree, complete genome

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum A3 str. Loch Maree was isolated from duck liver paste during a botulism outbreak at a hotel in the Scottish highlands in 1922. This was the first and worst outbreak of botulism in the United Kingdom (UK). This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
3584536537693sugar fermentation stimulation proteinQuickGO ontologyBLASTP
3659337081489hydrolase NUDIX familyQuickGO ontologyBLASTP
3719937921723hypothetical proteinBLASTP
3805538840786iron-sulfur cluster-binding proteinQuickGO ontologyBLASTP
3885939020162hypothetical proteinBLASTP
3940340107705thiF domain proteinQuickGO ontologyBLASTP
40190412991110major facilitator superfamily proteinQuickGO ontologyBLASTP
4132842272945acetyltransferase GNAT familyQuickGO ontologyBLASTP
4265944160150216S ribosomal RNAQuickGO ontologyBLASTP
4438247283290223S ribosomal RNAQuickGO ontologyBLASTP
47335474511175S ribosomal RNAQuickGO ontologyBLASTP
474574753478tRNA-LysQuickGO ontologyBLASTP
4773848334597uracil-DNA glycosylase family proteinQuickGO ontologyBLASTP
4919850699150216S ribosomal RNAQuickGO ontologyBLASTP
5092153822290223S ribosomal RNAQuickGO ontologyBLASTP
53874539901175S ribosomal RNAQuickGO ontologyBLASTP
539965407378tRNA-LysQuickGO ontologyBLASTP
5442854991564RNA polymerase sigma-70 factor familyQuickGO ontologyBLASTP
54988564301443hypothetical proteinBLASTP
5707558576150216S ribosomal RNAQuickGO ontologyBLASTP
5879861699290223S ribosomal RNAQuickGO ontologyBLASTP
61750618661175S ribosomal RNAQuickGO ontologyBLASTP
618736195078tRNA-PheQuickGO ontologyBLASTP
6221162351141hypothetical proteinBLASTP
6268363105423hypothetical proteinBLASTP
6324763360114hypothetical proteinBLASTP
6407965580150216S ribosomal RNAQuickGO ontologyBLASTP
6580268703290223S ribosomal RNAQuickGO ontologyBLASTP
68754688701175S ribosomal RNAQuickGO ontologyBLASTP
688776895478tRNA-PheQuickGO ontologyBLASTP
6909469837744peptidil-prolyl isomerase family proteinQuickGO ontologyBLASTP
7035971860150216S ribosomal RNAQuickGO ontologyBLASTP
7208274983290223S ribosomal RNAQuickGO ontologyBLASTP
75035751511175S ribosomal RNAQuickGO ontologyBLASTP
7528475463180sodium transporter family proteinQuickGO ontology
7552276265744NAD-dependent deacetylaseQuickGO ontologyBLASTP
763477642074tRNA-CysQuickGO ontology
7645177359909LD-carboxypeptidase family proteinQuickGO ontologyBLASTP
7739578336942transporter CorA metal ion transporter familyQuickGO ontologyBLASTP