Pre_GI Gene

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Host: NC_012563 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_012563:36000 Clostridium botulinum A2 str. Kyoto, complete genome

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain was isolated from a case of infant botulism in Kyoto, Japan in 1978. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
3605036742693sugar fermentation stimulation proteinQuickGO ontologyBLASTP
3679837286489hydrolase NUDIX familyQuickGO ontologyBLASTP
3740438126723hypothetical proteinBLASTP
3826039048789iron-sulfur cluster-binding proteinQuickGO ontologyBLASTP
3906739228162hypothetical proteinBLASTP
3961140315705thiF domain proteinQuickGO ontologyBLASTP
40398415071110major facilitator superfamily proteinQuickGO ontologyBLASTP
4153642480945acetyltransferase GNAT familyQuickGO ontologyBLASTP
4286744368150216S ribosomal RNAQuickGO ontologyBLASTP
4592646381456hypothetical proteinBLASTP
4645547111657hypothetical proteinBLASTP
47541476571175S ribosomal RNAQuickGO ontologyBLASTP
476634774078tRNA-LysQuickGO ontologyBLASTP
4796348559597uracil-DNA glycosylase family proteinQuickGO ontologyBLASTP
4942350924150216S ribosomal RNAQuickGO ontologyBLASTP
5248252937456hypothetical proteinBLASTP
5301153667657hypothetical proteinBLASTP
54099542151175S ribosomal RNAQuickGO ontologyBLASTP
542215429878tRNA-LysQuickGO ontologyBLASTP
5464055203564RNA polymerase sigma-70 factor familyQuickGO ontologyBLASTP
55200566421443hypothetical proteinBLASTP
5728758788150216S ribosomal RNAQuickGO ontologyBLASTP
6035160806456hypothetical proteinBLASTP
6088061536657hypothetical proteinBLASTP
61968620841175S ribosomal RNAQuickGO ontologyBLASTP
620916216878tRNA-PheQuickGO ontologyBLASTP
6242762567141hypothetical proteinBLASTP
6271462995282hypothetical proteinBLASTP
6323063388159protein DltDQuickGO ontologyBLASTP
6346563578114hypothetical proteinBLASTP
6429765798150216S ribosomal RNAQuickGO ontologyBLASTP
6735667811456hypothetical proteinBLASTP
6788568541657hypothetical proteinBLASTP
68972690881175S ribosomal RNAQuickGO ontologyBLASTP
690956917278tRNA-PheQuickGO ontologyBLASTP
6931270055744peptidil-prolyl isomerase family proteinQuickGO ontologyBLASTP
7057772078150216S ribosomal RNAQuickGO ontologyBLASTP
7223675137290223S ribosomal RNAQuickGO ontologyBLASTP
75187753031175S ribosomal RNAQuickGO ontologyBLASTP
7566176404744NAD-dependent deacetylase Sir2 familyQuickGO ontologyBLASTP
764867655974tRNA-CysQuickGO ontologyBLASTP
7659077498909LD-carboxypeptidase family proteinQuickGO ontologyBLASTP
7753478475942transporter CorA metal ion transporter familyQuickGO ontologyBLASTP