Pre_GI: BLASTN Hits

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Query: NC_009089:428075 Clostridium difficile 630, complete genome

Start: 428075, End: 466356, Length: 38282

Host Lineage: Peptoclostridium difficile; Peptoclostridium; Peptostreptococcaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is the epidemic type X variant that has been extensively studied in research and clinical laboratories. It produces both toxin A, and B. Causative agent of pseudomembranous colitis. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This species is now recognized as the major causative agent of pseudomembranous colitis (inflammation of the colon) and diarrhea that may occur following antibiotic treatment. This bacterium causes a wide spectrum of disease, ranging from mild, self-limiting diarrhea to serious diarrhea and, in some cases, complications such as pseudomembrane formation, toxic megacolon (dilation of the colon) and peritonitis, which often lead to lethality among patients. The bacteria produce high molecular mass polypeptide cytotoxins, A and B. Some strains produce only one of the toxins, others produce both. Toxin A causes inflammatory reaction involving hypersecretion of fluid and hemorrhagic necrosis through triggering cytokine release by neutrophils. Alteration of intestinal microbial balance with antibiotic therapy and increased exposure to the bacterium in a hospital setting allows C. difficile to colonize susceptible individuals. Moreover, it has been shown that subinhibitory concentrations of antibiotics promote increased toxin production by C. difficile.




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Islands with an asterisk (*) contain ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

Subject IslandStartEndLengthSubject Host DescriptionE-valueBit scoreVisual BLASTNVisual BLASTP
NC_009089:3935500*3935500397916543666Clostridium difficile 630, complete genome09943BLASTN svgBLASTP svg
NC_013316:40959054095905412999634092Clostridium difficile R20291, complete genome03313BLASTN svgBLASTP svg
NC_015977:29669712966971299209925129Roseburia hominis A2-183 chromosome, complete genome4e-170607BLASTN svgBLASTP svg
NC_013798:17787581778758180316524408Streptococcus gallolyticus UCN34, complete genome2e-32149BLASTN svgBLASTP svg
NC_013895:13328321332832138009947268Clostridiales genomosp. BVAB3 str. UPII9-5 chromosome, complete2e-32149BLASTN svgBLASTP svg
NC_021175:15976131597613162110823496Streptococcus oligofermentans AS 1.3089, complete genome2e-32149BLASTN svgBLASTP svg
NC_020291:11498871149887117209922213Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genome4e-31145BLASTN svgBLASTP svg
NC_009089:58165558165560656324909Clostridium difficile 630, complete genome9e-23117BLASTN svgBLASTP svg
NC_009089:38898113889811392148531675Clostridium difficile 630, complete genome2e-20109BLASTN svgBLASTP svg
NC_020291:1045058*1045058106857123514Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genome3e-1695.6BLASTN svgBLASTP svg
NC_015385:2050648*2050648208291832271Treponema succinifaciens DSM 2489 chromosome, complete genome5e-1591.7BLASTN svgBLASTP svg
NC_020291:15931431593143161363220490Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genome2e-1489.7BLASTN svgBLASTP svg
NC_009089:12830001283000132421841219Clostridium difficile 630, complete genome2e-1179.8BLASTN svgBLASTP svg
NC_002758:43446243446245281818357Staphylococcus aureus subsp. aureus Mu50, complete genome2e-1179.8BLASTN svgBLASTP svg
NC_016023:72984372984374912819286Bacillus coagulans 36D1 chromosome, complete genome2e-0869.9BLASTN svgBLASTP svg
NC_013798:17441181744118176331619199Streptococcus gallolyticus UCN34, complete genome2e-0869.9BLASTN svgBLASTP svg
NC_012984:26815482681548270409922552Lactobacillus plantarum JDM1, complete genome7e-0867.9BLASTN svgBLASTP svg
NC_013192:2381901*2381901240566523765Leptotrichia buccalis DSM 1135, complete genome1e-0663.9BLASTN svgBLASTP svg
NC_013192:171000*17100019590324904Leptotrichia buccalis DSM 1135, complete genome1e-0663.9BLASTN svgBLASTP svg
NC_004668:2198027*2198027227009972073Enterococcus faecalis V583, complete genome5e-0661.9BLASTN svgBLASTP svg