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Query: NC_009089:4177117:4183531 Clostridium difficile 630, complete genome

Start: 4183531, End: 4186077, Length: 2547

Host Lineage: Peptoclostridium difficile; Peptoclostridium; Peptostreptococcaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is the epidemic type X variant that has been extensively studied in research and clinical laboratories. It produces both toxin A, and B. Causative agent of pseudomembranous colitis. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This species is now recognized as the major causative agent of pseudomembranous colitis (inflammation of the colon) and diarrhea that may occur following antibiotic treatment. This bacterium causes a wide spectrum of disease, ranging from mild, self-limiting diarrhea to serious diarrhea and, in some cases, complications such as pseudomembrane formation, toxic megacolon (dilation of the colon) and peritonitis, which often lead to lethality among patients. The bacteria produce high molecular mass polypeptide cytotoxins, A and B. Some strains produce only one of the toxins, others produce both. Toxin A causes inflammatory reaction involving hypersecretion of fluid and hemorrhagic necrosis through triggering cytokine release by neutrophils. Alteration of intestinal microbial balance with antibiotic therapy and increased exposure to the bacterium in a hospital setting allows C. difficile to colonize susceptible individuals. Moreover, it has been shown that subinhibitory concentrations of antibiotics promote increased toxin production by C. difficile.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017179:3984000:3989086398908639916322547Clostridium difficile BI1, complete genomeABC transporter permease01598
NC_013315:3978495:3981066398106639836122547Clostridium difficile CD196 chromosome, complete genomeABC transporter permease01598
NC_014328:2990790:3003116300311630057042589Clostridium ljungdahlii ATCC 49587 chromosome, complete genomeputative permease01000
NC_012658:3678000:3686061368606136886342574Clostridium botulinum Ba4 str. 657 chromosome, complete genomeABC transporter ATP-binding protein0991
NC_004557:2037500:2043201204320120457892589Clostridium tetani E88, complete genomeABC transporter ATP-binding protein0991
NC_009706:2673906:268497726849772685558582Clostridium kluyveri DSM 555 chromosome, complete genomehypothetical protein5e-76286
NC_011837:2605409:261648026164802617061582Clostridium kluyveri NBRC 12016, complete genomehypothetical protein5e-76286
NC_009706:2673906:268411026841102684814705Clostridium kluyveri DSM 555 chromosome, complete genomehypothetical protein2e-71270
NC_004193:375416:3786443786443812502607Oceanobacillus iheyensis HTE831, complete genomehypothetical protein5e-60233
NC_004193:375416:375416375416675301299886Oceanobacillus iheyensis HTE831, complete genome7e-59229
NC_009706:2673906:268297526829752683478504Clostridium kluyveri DSM 555 chromosome, complete genomeABC transporter permease1e-56222
NC_009706:2673906:268349126834912684126636Clostridium kluyveri DSM 555 chromosome, complete genomehypothetical protein1e-50201
NC_014828:1987487:2007835200783520104472613Ethanoligenens harbinense YUAN-3 chromosome, complete genomeprotein of unknown function DUF2148e-24112
NC_014624:1549312:1559274155927415614752202Eubacterium limosum KIST612 chromosome, complete genomehypothetical protein2e-21105
NC_014328:85290:1014801014801038612382Clostridium ljungdahlii ATCC 49587 chromosome, complete genomeputative ABC transporter permease7e-1583.2
NC_014376:2964731:2967080296708029694072328Clostridium saccharolyticum WM1 chromosome, complete genomeprotein of unknown function DUF2142e-1068.6
NC_012778:1573847:1573847157384715762912445Eubacterium eligens ATCC 27750, complete genomehypothetical protein1e-0965.9
NC_013171:824917:8400078400078424422436Anaerococcus prevotii DSM 20548, complete genomeprotein of unknown function DUF2141e-0655.8
NC_016627:4159406:4169504416950441720442541Clostridium clariflavum DSM 19732 chromosome, complete genomelipoprotein release ABC transporter permease4e-0654.3
NC_015172:1195782:1230220123022012325382319Syntrophobotulus glycolicus DSM 8271 chromosome, complete genomeprotein of unknown function DUF2145e-0653.9
NC_017303:1836500:1851459185145918540592601Corynebacterium pseudotuberculosis I19 chromosome, complete genomeantimicrobial peptide ABC transporter6e-0653.5
NC_017300:1833772:1849025184902518516252601Corynebacterium pseudotuberculosis 1002 chromosome, completeantimicrobial peptide ABC transporter6e-0653.5
NC_016048:751000:7769637769637787741812Oscillibacter valericigenes Sjm18-20, complete genomehypothetical protein7e-0653.5