Pre_GI Gene

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Host: NC_004557 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_004557:2037500 Clostridium tetani E88, complete genome

Host Lineage: Clostridium tetani; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is a virulent nonsporulating variant of strain Massachusetts used in vaccine production. Causes tetanus. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Known opportunistic toxin-producing pathogens in animals and humans. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This organism causes tetanus (lockjaw) in humans. At the tissue level, the bacterium then releases an exotoxin called tetanospasmin that causes certain nervous system irregularities by means of retrograde tramsmission through neurons to the brain. If nervous impulses cannot be checked by normal inhibitory mechanisms, it produces the generalized muscular spasms characteristic of tetanus.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
203768720394951809hypothetical proteinBLASTP
203948520424722988hypothetical protein
204320120457892589ABC transporter ATP-binding proteinQuickGO ontologyBLASTP
20457862046490705ABC transporter ATP-binding proteinQuickGO ontologyBLASTP
204655220475711020sensor protein resEQuickGO ontologyBLASTP
20475282048214687regulatory component of sensory transduction systemQuickGO ontologyBLASTP
20482112048780570putative transposaseQuickGO ontologyBLASTP
20497932050185393transporterQuickGO ontology
20505172051134618catabolite gene activatorQuickGO ontologyBLASTP
20512342051860627membrane spanning proteinQuickGO ontologyBLASTP
205187620525506752-haloalkanoic acid dehalogenase IQuickGO ontologyBLASTP
20528942053541648putative transcriptional regulatorQuickGO ontologyBLASTP
20539032054295393hypothetical proteinBLASTP
20545492054896348hypothetical proteinBLASTP
205493020560031074chromosome partitioning parB family proteinQuickGO ontologyBLASTP
20561432056634492hypothetical proteinBLASTP
20567962057179384death on curing proteinQuickGO ontologyBLASTP