Pre_GI: BLASTN Hits

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Query: NC_003366:461602 Clostridium perfringens str. 13, complete genome

Start: 461602, End: 484355, Length: 22754

Host Lineage: Clostridium perfringens; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is a type A isolate from the soil. It can establish gas gangrene in a murine experimental model. Causative agent of gas gangrene. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism is a causative agent of a wide spectrum of necrotic enterotoxicoses. It also causes such animal diseases as lamb dysentery, ovine enterotoxemia (struck), pulpy kidney disease in lambs and other enterotoxemias in lambs and calves. It is commonly found in the environment (soil, sewage) and in the animal and human gastrointestinal tract as a member of the normal microflora. It is a fast growing (generation time 8-10 min) anaerobic flesh-eater. Active fermentative growth is accompanied by profuse generation of molecular hydrogen and carbon dioxide. It is also oxygen tolerant which makes it an easy object to work with in laboratories. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. All types produce the alpha toxin (phospholipase C). Type A strains that cause gas gangrene produce alpha toxin, theta (hemolysin), kappa (collagenase), mu (hyaluronidase), nu (DNAse) and neuraminidase which are all the enzymatic factors aiding the bacterium in invading and destruction of the host tissues. Type C strains produce alpha toxin, beta toxin and prefringolysin enteritis. In addition to alpha toxin, Type B strains produce beta toxin, types B and D produce the pore forming epsilon toxin and type E strains produce iota toxin.




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Islands with an asterisk (*) contain ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

Subject IslandStartEndLengthSubject Host DescriptionE-valueBit scoreVisual BLASTNVisual BLASTP
NC_013171:75110*751109951724408Anaerococcus prevotii DSM 20548, complete genome4e-0867.9BLASTN svgBLASTP svg
NC_010520:3674883*3674883369898424102Clostridium botulinum A3 str. Loch Maree, complete genome1e-32149BLASTN svgBLASTP svg
NC_014393:503230*50323052309919870Clostridium cellulovorans 743B chromosome, complete genome1e-0869.9BLASTN svgBLASTP svg
NC_009089:3935500*3935500397916543666Clostridium difficile 630, complete genome1e-20109BLASTN svgBLASTP svg
NC_014328:34829803482980351005727078Clostridium ljungdahlii ATCC 49587 chromosome, complete genome7e-0763.9BLASTN svgBLASTP svg
NC_014328:303063*30306337786274800Clostridium ljungdahlii ATCC 49587 chromosome, complete genome1e-1179.8BLASTN svgBLASTP svg
NC_021182:3525523*3525523356673741215Clostridium pasteurianum BC1, complete genome1e-29139BLASTN svgBLASTP svg
NC_008261:576923*57692359692520003Clostridium perfringens ATCC 13124, complete genome1e-1179.8BLASTN svgBLASTP svg
NC_008261:421000*42100043770016701Clostridium perfringens ATCC 13124, complete genome02716BLASTN svgBLASTP svg
NC_008262:419726*41972644060220877Clostridium perfringens SM101, complete genome02613BLASTN svgBLASTP svg
NC_020134:17830001783000180159918600Clostridium stercorarium subsp. stercorarium DSM 8532, complete3e-0971.9BLASTN svgBLASTP svg
NC_004557:691944*69194471563123688Clostridium tetani E88, complete genome7e-1073.8BLASTN svgBLASTP svg
NC_012440:1215838*1215838124846532628Persephonella marina EX-H1, complete genome2e-0765.9BLASTN svgBLASTP svg
NC_012925:14000014000016217622177Streptococcus suis P1/7, complete genome1e-0869.9BLASTN svgBLASTP svg