Pre_GI Gene

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Host: NC_010520 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_010520:3674883 Clostridium botulinum A3 str. Loch Maree, complete genome

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum A3 str. Loch Maree was isolated from duck liver paste during a botulism outbreak at a hotel in the Scottish highlands in 1922. This was the first and worst outbreak of botulism in the United Kingdom (UK). This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
367488336760791197hypothetical proteinBLASTP
36766013676876276hypothetical proteinBLASTP
36776043677744141hypothetical protein
36778173678353537putative flavoredoxinQuickGO ontologyBLASTP
36797303679891162hypothetical protein
36807813681227447acetyltransferaseQuickGO ontologyBLASTP
36815273681682156hypothetical proteinBLASTP
36821013682805705hypothetical proteinBLASTP
36828523683637786AraC-family transcriptional regulatorQuickGO ontologyBLASTP
36836163683765150hypothetical protein
36839583684233276methyltransferase UbiECOQ5 familyQuickGO ontologyBLASTP
36843533684757405cytidinedeoxycytidylate deaminase family proteinQuickGO ontologyBLASTP
36849073685845939NAD-dependent epimerasedehydrataseQuickGO ontologyBLASTP
36863813686902522riboflavin biosynthesis protein RibD C- domain proteinQuickGO ontologyBLASTP
368689936893912493excinuclease ABC A subunitQuickGO ontologyBLASTP
36893953689814420transcriptional regulator MarR familyQuickGO ontologyBLASTP
36901803691124945hypothetical proteinBLASTP
36913283691729402putative transcriptional regulatorQuickGO ontologyBLASTP
36919493692356408acetyltransferase GNAT familyQuickGO ontologyBLASTP
36927823694167138623S rRNA uracil-5--methyltransferase RumAQuickGO ontologyBLASTP
36944003694753354hypothetical proteinBLASTP
369508136960911011oxidoreductase aldoketo reductase familyQuickGO ontologyBLASTP
369623436979911758pyruvate kinaseQuickGO ontologyBLASTP
369802536989849606-phosphofructokinaseQuickGO ontologyBLASTP